Serum Lipids and Total Antioxidant Concentration in Alloxanized Diabetic Rats.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 3
Abstract
This study was designed to determine the serum levels of lipids and TAC as biomarkers of cardiovascular complications and oxidative stress respectively in diabetic wistar rats. 20 albino wistar rats weighing between 150g and 200g were used in this study, they were divided into two equal groups. Group I was the control while Group II was the diabetic group. The animals were handled according to the institutional and international guidelines for the care and use of laboratory animals. Diabetes was induced in group II by a single intraperitoneal injection of alloxan monohydrate (150mg/kg body weight) while group I received normal saline. After four weeks, blood samples were collected after an overnight fast for biochemical assays. The mean Fasting Plasma Glucose FPG, Glycated Hemoglobin HbA1c, total cholesterol TC, low density lipoprotein LDL, very low density lipoprotein VLDL and triglyceride TG concentrations were significantly (p<0.05) elevated while high density lipoprotein HDL and total antioxidant concentrations TAC were significantly (p<0.05) reduced in the diabetic group when compared to the control group. From our study therefore, untreated diabetes resulted in alterations in the serum lipids as well as total antioxidant concentrations.
Authors and Affiliations
Obi-Ezeani C. N1, Ogundeji E. B2, Nwagbara I. J, Chukwu C. C4
Keywords
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