Serum Th1/Th2 Cytokine Levels During Acute Mumps Infection: Prediction To Infertility Patients with History of Mumps Infection
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 5
Abstract
Background: Mumps is the best-known cause inflammation of the testicles, reduced testosterone level, failure of sperm production and lead to infertility. The hypothesis of this study is to know mumps virus may be the cause of infertility in patients who have infertility problem with history of mumps infection. It is with this notion we aimed to compare and link the Th1/Th2 cytokine levels between acute mumps patients and infertility patients with history of mumps. Methods: Mumps specific IgM, MMR specific IgG antibody and Th1/Th2 cytokines, namely interferon-γ (IFNγ), interleukin-2 (IL-2), IL-4 and IL-10 were measured simultaneously in serum from acute mumps cases, infertility cases, control subjects and supernatant of PBMCs stimulated with mumps virus. Hormonal evaluation (testosterone, FSH and LH) and spermatograms were measured for infertility cases. Statistical significance was analysed between each group by means of Mann-Whitney U test, Kruskal–Wallis test and Spearman’s rank correlation coefficient test. Result: Significant reduction of testosterone, an increased FSH & LH levels, greatly reduced sperm count, and severe abnormalities in motility and morphology seen in infertility patients with history of mumps. Also IFN-γ and IL-2 showed a significant increase in groups, acute mumps pediatrics cases (Group A), adult cases (Group B), and infertile with history of mumps infection (Group C). IL-10 level significantly deceased in group C when compared to group A and B. Conclusion: Upon evaluation of hormonal levels and spermatograms confirms the mumps virus can be the possible reason for the infertility in group C patients and Th1 cells play important roles during the acute phase in the pathogenesis of mumps and infertility with history of mumps.
Authors and Affiliations
Jeevan Malaiyan, Sanjeeva Reddy Nellapillai, Padmasani Venkat Ramanan, Abinaya Gokul
Keywords
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- EP ID EP597068
- DOI 10.9790/0853-1605038390.
- Views 110
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