SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF TRETINOIN AND CURCUMIN COMBINATION IN PURE FORM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 9
Abstract
The present study is very optimistic towards the development in dosage forms loaded with synthetic and herbal drug combination. The simultaneous estimation was done by using spectrophotometric method, using ethanol as solvent. Stock solutions of Tretinoin and Curcumin were diluted to final concentration of 5µg/ml. UV scan of 5µg/ml solution of both drugs combination showed the absorption maxima at 349.2 nm and 427.2 nm. respectively by using ethanol as blank. Simultaneous estimation method also indicates the interference between both the drugs at their respective λ max of one another. By replacing A1, A2, E1a, E1b, E2a and E2b values in simultaneous equation, C1 and C2 were calculated and found 4.94 µg/ml and 5.0 µg/ml respectively. The method developed was found suitable as percentage recovery was 99% and 100% for Curcumin and Tretinoin respectively indicating no interference between both the drugs.
Authors and Affiliations
Santanu Mallik , M. D. Kshirsagar , Vipin Saini
Keywords
Related Articles
- EP ID EP86482
- DOI -
- Views 117
- Downloads 0
BIOREMEDIATION OF PICOLINE BY ADAPTING P. AERUGINOSA ISOLATED FROM INDUSTRIAL EFFLUENT POLLUTED WATER
Environmental pollution implies any alteration in the surroundings but it is restricted in use especially to mean any deterioration in the physical, chemical, and biological quality of the environment. All types of pollu...
IN VIVO EVALUATION OF HYPOGLYCEMIC ACTIVITY OF SOLID DISPERSIONS OF GLIBENCLAMIDE USING PREGELATINISED STARCH AS A SOLUBILITY ENHANCER
Current study was undertaken to investigate the aptness of pregelatinised starch to get better solubility and In vitro dissolution rate of the poorly water soluble drug glibenclamide. Physical mixtures, kneading mixtures...
ANALYSIS OF PHYTOCHEMICAL COMPOSITION AND BACTERIOSTATIC ACTIVITY OF TAGETES SP
Present study was carried out to investigate the antimicrobial effect of ethanolic extracts of leaves and flowers of Tagetes erecta Linn and Tagetes patula Linn. After performing preliminary phytochemical screening and...
SYNTHESIS AND SCREENING OF SOME DIHYDROPYRIMIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS
The wide applications of pyrimidine fused heterocyclic compounds prompted us to synthesize a new series of dihydropyrimidine derivatives through Biginelli reaction. The synthesized compounds were characterized by IR and...
PHARMACOVIGILANCE IN GERIATRICS
Pharmacovigilance has gained significant importance with increased number of drugs molecules entering the market and the increase in the number of drug recalls due to the involvement of high health risks incident. It has...