Spectrophotometric Methods for Simultaneous Estimation of Paracetamol and Diclofenac Sodium in Combined Dosage Form by Application of Hydrotropic Solubilization
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 12
Abstract
In the present investigation, 1.0 M urea solution was employed as hydrotropic solubilizing agent to solubilize poorly water-soluble drug paracetamol for its spectrophotometric analysis. The proposed method is new, simple, environmentally friendly, accurate, reproducible, precise and validated statistically for simultaneous estimation of paracetamol and diclofenac sodium in bulk drug and tablet dosage form. Simultaneous equation method, absorption ratio method and dual wavelength method have been used in the estimation of both the drugs. All the three methods show good accuracy and precision which was validated statistically. The optimized methods showed good reproducibility and recovery with standard deviation of < 1.0% and percent relative standard deviation less then 2.0%, standard error in case of recovery studies are satisfactorily low and allow the simultaneous estimation of paracetamol and diclofenac sodium in concentration ranges employed for this purpose in the assay of bulk drug and tablets. It is, thus, concluded that the proposed method is new, simple, cost-effective, safe, accurate, precise and environmentally friendly. This method can be successfully employed in the routine analysis of both the drugs in tablet dosage form.
Authors and Affiliations
Rajesh Sharma , Geetam Pathodiya , Ganesh Prasad Mishra , Jitendra Sainy
Keywords
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