STABILITY OF MARKETED ALBENDAZOLE SUSPENSIONS AND CORRELATION BETWEEN ZETA POTENTIAL AND SEDIMENTATION
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
The study was aimed at evaluating the stability of marketed albendazole suspension through electrokinetic characterization of the particles. The marketed brands of Albendazole suspension that were studied include AVIZOLE®, BENTAL®, BENDEX®, NOWORM® and ZENTAL®. Particle size, zeta potential, sedimentation volume, viscosity and pH of the suspension were the parameters determined and their correlation was established. ZENTAL® showed maximum sedimentation volume and its zeta potential was also found to be the highest. Rheological studies of the suspension displayed maximum viscosity with ZENTAL®. Particle size analysis showed that ZENTAL® had least size. From the study it is evident that particle size, zeta potential and sedimentation volume have an influence on the suspension stability.
Authors and Affiliations
Pushkar Sharma , Shaila Lewis
Keywords
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