Strategies for neuroprotection following spinal cord injury
Journal Title: Ortopedia Traumatologia Rehabilitacja - Year 2009, Vol 11, Issue 2
Abstract
Progress in neuropathology has made possible the description of local responses of neural tissue in early stages after traumatic spinal cord injury (SCI). The recent identification of multiple factors responsible for secondary spinal cord damage and for potential regenerative abilities has not resulted in the development of a standard for neuroprotective therapy in SCI patients.The paper reviews current knowledge concerning the sequence of biochemical events in the injured spinal cord and gives an overview of therapeutic possibilities for preventing the spread of secondary injury.The literature survey has led to the following conclusions: 1. The primary zone of traumatic damage enlarges due to local vascular disturbances, hypoxia, and the resulting inflammation. 2. Inflammation in the region of secondary injury, apart from having a destructive impact, is the source of substances which may induce neural tissue repair. 3. The administration of methylprednisolone and surgical decompression of the spinal cord within several hours after SCI improves functional and neurological outcomes in patients with incomplete neurological deficits. Currently there is no sufficient scientific evidence to support the safety and efficacy of other neuroprotective methods in humans.
Authors and Affiliations
Piotr Tederko, Marek Krasuski , Jerzy Kiwerski , Izabela Nyka, Dariusz Białoszewski
Keywords
Related Articles
- EP ID EP56889
- DOI -
- Views 116
- Downloads 0
Wpływ terapii manualnej na odczucie bólu, sprawność oraz siłę chwytu rąk u chorego z reumatoidalnym zapaleniem stawów. Dydaktyczne studium przypadku
Reumatoidalne zapalenie stawów (RZS) jest immunologicznie zależną, zapalną układową chorobą tkanki łącznej, prowadzącą do uszkodzenia stawów i powikłań narządowych. W ostatnich latach obserwuje się duże zainteresowanie t...
Edema-protective agents in postoperative disturbances of venous and lymphatic microcirculation in the lower limbs.
Clinical observations indicate that impairment of venous and lymphatic microcirculation is a major complication of orthopedic surgery. Usually it is older patients with certain risk factors that are affected. The symptom...
Influence of degenerative changes in shoulder joints at ill after the cerebral stroke for the returnof the function of the uppelimp
Introduction: with Frequent complications appearing at ill there are disorders of the function and pathological changes in structures of a shoulder joint after the cerebral stroke. Degenerative changes overlapping each o...
Predicting Persistent Unclear Pain Following Primary Total Knee Arthroplasty
Chronic post-surgical pain can be a considerable issue for patients undergoing primary total knee arthroplasty. According to the literature, persistent knee pain is experienced by up to 44% of patients. Most studies on t...
The effect of high tone power therapy on gait range in patients with chronic lower limb ischaemia
Background: Pain-related abnormalities of the economy of walking are the most important factor adversely affecting overall physical activity of patients with chronic lower limb ischaemia. These patients are routinely man...