STUDIES IN DISSOLUTION ENHANCEMENT OF ATENOLOL USING HP-βCD
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 8
Abstract
Atenolol β1 cardio selective adrenoreceptor blocking agent, which is poorly soluble with only 40-50% bioavailability. In the present study attempt has been made to prepare and characterize inclusion complexes of Atenolol with HP-β-CD.The phase solubility analysis indicated the formation of 1:1 molar inclusion complex of atenolol with HP- β-CD. Apparent stability constant ( KC) was 43.195 M-1 for HP- β-CD complexes. The inclusion complexes were prepared by three different methods viz. physical, kneading, co-precipitation method. The prepared complexes were characterized using solubility study, differential scanning calorimetry and X-Ray diffractometry. The inclusion complex prepared with HP- β-CD by co-precipitation method exhibited greatest enhancement in solubility and fastest dissolution (102.015% drug release in 45 min) of Atenolol.
Authors and Affiliations
Prashant Ghule , Saumya Das , Ganesh Karle
Keywords
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