Study of base influence on intensity of vinpocetine releasing from nasal soft dosage forms
Journal Title: Фармацевтичний журнал - Year 2014, Vol 2, Issue 2
Abstract
At present pharmacotherapy is the main component in successful treatment of cerebrovascular pathology. Besides an arsenal of effective medications of conclusive medicine in this area is limited. The one of medications for selective correction of cerebral perfusion is vinpocetine. Defects of its peroral and injection use can be improved by transmucosal vinpocetine administration such as intranasal with suitable semisolid dosage forms. The aim of this work is study of base influence on vinpocetine releasing from nasal semisolid dosage forms. As the carrier for developing vinpocetine nasal semisolid dosage form hydrophilic, hydrophobic and emulsion bases which are used in manufacturing, widely described in literature and don’t provoke any allergic or sensitizing reactions were studied. Further investigation for scientific substantiation choice of base for vinpocetine nasal semisolid dosage form was carried out by the one-factor-at-a-time dispersion design with repeated observations. For all selected compositions the vinpocetine releasing was ascertained with equilibrium dialysis method by Kruvchinsky through cellophane membrane as the first stage of bioavailability evaluation. It was determined that the base makes significant influence on vinpocetine releasing. Dispersion analysis of results presented that emulsion base oil/water provides with the optimal vinpocetine releasing.
Authors and Affiliations
N. O. Nagornaya, V. V. Gladishev, B. S. Burlaka, I. L. Kеchin
Keywords
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