Study of Serum High Sensitive C - Reactive Protein Level in Hyperthyroid Patients
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 2
Abstract
Background: C-reactive protein (CRP) is widely known as sensitive marker of low grade inflammation and a well-known independent predictor for atherosclerosis. Elevated level of thyroid hormones in overt hyperthyroidism leads to hyperdynamic state of cardiovascular system. However, relation between increased thyroid hormones and low grade inflammation is not clear. Therefore the present study was designed to investigate hs-CRP in patients suffering with hyperthyroidism. Methods: Fifty-three patients with hyperthyroidism and forty-five healthy control subjects of age (40.2 ± 13.6 yrs and 39.8 ± 7.7yrs, p>0.05) and BMI (24.2 ± 4.6 kg/m2 and 23.8 ± 4.3 kg/m2, p>0.05) were included in this study. Serum concentrations of free T4 (fT4), fT3, TSH, and lipid profile total cholesterol, triglyceride, high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C) were estimated in all subjects. Serum hs-CRP levels were assessed by ELISA method. Results: A significant difference between total cholesterol (p< 0.01) and LDL-C levels (p< 0.01) of hyperthyroid group were lower than the control group. There was a significant difference in hs-CRP level between hyperthyroid patients group (0.52± 0.12) and control groups (0.049±0.02). Further, a significant correlation of hs-CRP was observed with FT3, FT4 and TSH (r= 0.298, p<0.01, r= 0.278, p<0.01 and r= -0.235, p<0.01) in hyperthyroid group. Conclusion: Finding of the present study suggest that hyperthyroidism is associated with low grade inflammation which leads to the development of atherosclerosis. Moreover, hs-CRP can be an important biomarker for the atherosclerosis in hyperthyroid patients.
Authors and Affiliations
Vikash Goyal, Prem Narayan Vais
Keywords
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- EP ID EP538002
- DOI 10.21276/ijmrp.2018.4.2.013
- Views 59
- Downloads 0
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