Study on the change of neutralizing antibody level in plasma donors after a third shot of inactivated novel coronavirus vaccine
Journal Title: Chinese Journal of Blood Transfusion - Year 2023, Vol 36, Issue 5
Abstract
Objective To investigate the trend of neutralizing antibody level in plasma donors who received the 3rd shot of inactivated novel coronavirus vaccine. Methods Three commercial ELISA kits for novel coronavirus neutralization antibody detection, manufactured by Company A, B and C, were chosen and screened by Pseudotype Neutralization Test from December 2021 to June 2022. A total of 410 plasma samples from 64 plasma donors who received the 3rd shot of inactivated novel coronavirus vaccine and there after donated plasma within six months were detected by the selected ELISA kit from July to October, 2022. The data were analyzed by Excel 2013 and SPSS 26 software. Results The high-throughput ELISA kit for SARS-CoV-2 neutralizing antibody detection, manufactured by Company A, was selected for further antibody titer detection. The mixed plasma titers were 1 337.34, 1 148.89, 852.19, 681.38, 556.44 and 457.19 U/mL from 1 to 6 months, respectively, after the 3rd shot of vaccine. The neutralizing antibody titer level began to increase around 7 days after the 3rd shot of vaccine injection and peaked (peak range: 264.07-2 208.39 U/mL, median: 569.34 U/mL) at 1 month (range: 9-43 days, median: 22 days), and then gradually decreased (P<0.05). Conclusion The neutralizing antibody titer of plasma donors who received the 3rd shot of inactivated novel coronavirus vaccine began to rise around 7 days after vaccination, which reached the peak value at around 1 month and then gradually decreased.
Authors and Affiliations
Wenjuan GE, An ZHOU, Junying SHEN, Xiaoqing LI, Jie MA, Mengzhao ZHU, Changyong JIAN
Keywords
Related Articles
- EP ID EP738545
- DOI 10.13303/j.cjbt.issn.1004-549x.2023.05.009
- Views 50
- Downloads 0
Investigation and analysis of characteristics and mobility of the overlapping population of voluntary blood donation and plasmapheresis donation
Objective To analyze the characteristics and mobility of the overlapping population of voluntary blood donation and plasmapheresis donation, so as to provide a scientific basis for the formulation of recruitment and rete...
Establishment and evaluation of predictive models of platelet transfusion effect in multi-center tumor patients
Objective To study the platelet transfusion predictive models in tumor patients and evaluate its application effect. Methods A retrospective study was conducted on 944 tumor patients, including 533 males and 411 females...
Research progress in clinical application of lymphoplasmapheresis in immune-related diseases
Lymphoplasmapheresis(LPE) is a combination of plasma exchange and lymphocyte separation technology. It can not only remove autoimmune antibodies, but also remove the immune active cells producing these antibodies. At the...
Investigation on the prevalence of human parvovirus B19 infection among voluntary blood donors
Objective To investigate the infection of human parvovirus B19 in Suzhou voluntary blood donors under the current blood screening model. Methods A total of 893 blood donor samples from September to December 2022 were ran...
Practice of paper-free whole blood collection system in constructing intelligent blood station
Objective To establish a paper-free system of the total whole blood donation flow in constructing intelligent blood stations, and build digitalized whole blood donation system for practice. Methods A paper-free whole blo...