Survival in surgical non-small cell lung cancer in a French Hospital
Journal Title: JOURNAL OF FUNCTIONAL VENTILATION AND PULMONOLOGY - Year 2019, Vol 10, Issue 30
Abstract
Background. Lung cancer staging with positron emission tomography, and adjuvant treatments (AT) have been progressively used for the management of surgical non-small cell lung cancer (NSCLC). Aim and methods. The objective of this retrospective study was to analyze the survival of surgically NSCLC in a French University hospital. This study included 1 562 patients between 1988 and 2011. Patients were assigned into 2 groups: G1=before PET, and AT introduction (19882002); G2=after PET, and AT introduction (2003-2011). Patients’ clinical profile and survival were described, and compared using the Kaplan-Meïer method and Log-rank test. A multivariate analysis was conducted with a Cox model. Results. Adenocarcinoma was the most frequent histological types in G2 (38.8%, p<0.0001). The percentage of women (G2: 21.2% vs G1: 13.1%, p<0.0001) as well as of non-smokers increased over time (7.3% vs 6.9%, p=0.009), and also for early stages NSCLC (29.2% vs 15.5%, p<0.0001). Comparing G2 to G1, more patients underwent an association of chemotherapy and radiotherapy after surgery (4.9% vs 1.2%), and postoperative chemotherapy was also more frequent (20.8% vs 6.5%, p<0.0001). G2 patients vs G1 had a better one-year survival (70% vs 48%, p<0.0001). Women had a better survival for the whole cohort (HR<0.0001), in G1 (HR<0.0001), and G2 (HR=0.03). The Cox model found a lower risk in G2 period (HR=0.52 [0.40–0.66] for adenocarcinoma, and HR=0.64 [0.50–0.80] for squamous carcinoma. Conclusions. The survival of surgically NSCLC raised since 2003, with probably an impact of epidemiological, diagnostic, and therapeutic changes.
Authors and Affiliations
CHRISTELLE CLÉMENT-DUCHÊNE
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- EP ID EP570787
- DOI 10.12699/jfvpulm.10.30.2019.9
- Views 61
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