Survival in surgical non-small cell lung cancer in a French Hospital
Journal Title: JOURNAL OF FUNCTIONAL VENTILATION AND PULMONOLOGY - Year 2019, Vol 10, Issue 30
Abstract
Background. Lung cancer staging with positron emission tomography, and adjuvant treatments (AT) have been progressively used for the management of surgical non-small cell lung cancer (NSCLC). Aim and methods. The objective of this retrospective study was to analyze the survival of surgically NSCLC in a French University hospital. This study included 1 562 patients between 1988 and 2011. Patients were assigned into 2 groups: G1=before PET, and AT introduction (19882002); G2=after PET, and AT introduction (2003-2011). Patients’ clinical profile and survival were described, and compared using the Kaplan-Meïer method and Log-rank test. A multivariate analysis was conducted with a Cox model. Results. Adenocarcinoma was the most frequent histological types in G2 (38.8%, p<0.0001). The percentage of women (G2: 21.2% vs G1: 13.1%, p<0.0001) as well as of non-smokers increased over time (7.3% vs 6.9%, p=0.009), and also for early stages NSCLC (29.2% vs 15.5%, p<0.0001). Comparing G2 to G1, more patients underwent an association of chemotherapy and radiotherapy after surgery (4.9% vs 1.2%), and postoperative chemotherapy was also more frequent (20.8% vs 6.5%, p<0.0001). G2 patients vs G1 had a better one-year survival (70% vs 48%, p<0.0001). Women had a better survival for the whole cohort (HR<0.0001), in G1 (HR<0.0001), and G2 (HR=0.03). The Cox model found a lower risk in G2 period (HR=0.52 [0.40–0.66] for adenocarcinoma, and HR=0.64 [0.50–0.80] for squamous carcinoma. Conclusions. The survival of surgically NSCLC raised since 2003, with probably an impact of epidemiological, diagnostic, and therapeutic changes.
Authors and Affiliations
CHRISTELLE CLÉMENT-DUCHÊNE
Keywords
Related Articles
- EP ID EP570787
- DOI 10.12699/jfvpulm.10.30.2019.9
- Views 67
- Downloads 0
Study of changes in clinical symptoms and some biologic parameters in asthma patients allergic to D.pteronyssinus treated by sublingual and subcutaneous immunotherapy
Introduction. Although subcutaneous immunotherapy (SCIT) is traditional method for allergic asthma treatment, it has disadvantages that are the reasons why patients refuse the treatment. However, Sublingual immunotherapy...
The role of induced sputum eosinophils in asthma
Over the last decades, the analysis of inflammatory cells by induced sputum, especially for eosinophils in asthmatic patients help physicians to a better understanding of airway inflammation in these patients [1]. Induce...
About a cervico-mediastinal fluid collection
Mediastinal locations of Hodgkin's lymphomas are quite common. They can be revealed by an infectious syndrom and atypical radiological images leading to a wandering diagnosis and a therapeutic delay. We present the case...
Knowledge and attitudes of the students of the Niamey Faculty of Health Sciences on tobacco
During these last 10 years we note a growing consumption of the tobacco especially that of chicha by the young Nigeriens. This pushed us to do this work. It was a prospective cross-sectional study over 20 months (January...
Chemotherapy use at the end of life in metastatic non small cell lung cancer: practical analysis
Background. End of life cancer care has become more aggressive. Scarce studies have explored the factors associated with the aggressiveness of cancer care near the end of life (EOL) in non-small cell lung cancer (NSCLC)...