Synthesis and Evaluation of Some Novel N, NDialkylaminoalkoxy-2-Oxo-Indole-3-Ylidene Benzohydrazides as Anticonvulsant Agents
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 2
Abstract
A series of N,N-dialkylaminoalkoxy-2-Oxo-indole-3-ylideneBenzohydrazides were synthesized by using the well designed synthetic route and the purity of the compounds were assessed by TLC, and characterized by FT-IR, NMR spectral data. The anti-convulsant activities of the synthesized compounds were evaluated against MES and PTZ induced seizure models in mice. All the test compounds were administered at doses of 50mg/kg body weight orally for MES method. The stimulus parameters in mice were 50mA in a pulse of 60Hz for 200ms. Intraperitonially for a PTZ method from the series of compounds it was noted that compound N,N-dimethylaminoPropoxy-2-Oxo-5-methyl-3-ylidenebenzo hydrazides(VIIb) protected more than 80% of the mice against MES and PTZ induced seizures compound VIId, VIIa, VIIe were found to be next in the order of reducing the duration of convulsions in both MES and PTZ methods. Molecular docking studies were also carried out by using windows 2007 using Moe 2008.10 version. The 5HT2c mouse receptor was retrieved from the protein data bank and used as target receptor was retrieved from the protein data bank.
Authors and Affiliations
Sravanthi Madhira, Kiranmai Mandava, Sarangapani Manda, Sai Prasanna R a ,, Vijayalaxmi Ta
Keywords
Related Articles
- EP ID EP388562
- DOI 10.9790/3008-1202028493
- Views 66
- Downloads 0
Molecular characterization of some food borne pathogens in soft cheese samples collected from Jeddah, Saudi Arabia
The growing industrial attention toward rapid methods and the wide use of nucleic acid amplification techniques has led for developing and applying of PCR based methods for food-borne pathogens recognition. In the curren...
White Oyster Mushroom Effect Of Lowering Cholesterol Levels And Prevention Atherosclerosis In Wistar Male Rats Are Given High Cholesterol Feed.
Atherosclerosis is a degenerative disease which onset can be accelerated by consuming foods high cholesterol. To prevent the formation of atherosclerosis is reduce of cholesterol levels. Objective: To determine the effec...
Effect of Aloe vera gel on lipid profile and some serum biomarkers of liver function in high salt fed Wistar rats
This study examined the effect of Aloe vera gel on lipid profile and some serum biomarkers of liver function in high salt-fed wistar rats. Twenty male wistar rats (200-250g) were randomly assigned into four groups (n=5):...
Role of Cinnamon Extract in the Protection against Amoxicillin/Clavulanate-Induced Liver Damage in Rats
Amoxicillin/clavulanate (AC), which is effectively used in the treatment of several number of bacterial infections, may cause hepatotoxicity. Cinnamon extract contains natural products which showed antioxidant, anti-infl...
Levels of Heavy Metals in Some Soup Thickeners Used In Abomege in Ebonyi State, Nigeria
Samples of Afzelia Africana, Brachystogia Nigerica and Macuna-sloanei, were collected from Abaomege in Onicha L.G.A of Ebonyi State and were analyzed for heavy metals using Atomic Absorption Spectrophotometer (Bulk scien...