SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL N-SUBSTITUTED-5-OXA-IMIDAZOLE
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1
Abstract
Various substituted 2-(2'-phenyl-4'-p-dimethylaminobenzylidenyl imidazolin-5'-one)-6-fluoro-7- substituted (1,3) benzothiazoles and 2-(2'-phenyl-4'-o-hydroxy benzylidenyl-5'oxo imidazolin-1-yl amino) - 6-fluoro-7-substituted (1,3) benzothiazoles containing different functional groups have been synthesized by treating substituted 2-aminobenzothiazoles with oxozolone in presence of dry pyrirdine. The identity of compounds were confirmed on the basis of their spectral (UV-Visible, IR, 1H NMR and Mass) data. Further, they have been screened for their antimicrobial, antiinflammatory, anticonvulsant and anthelmintic activities.
Authors and Affiliations
Shameer H, Nageswara Rao R, Vijay Kumar MMJ, Jayachandran E, Sreenivasa GM
Keywords
Related Articles
- EP ID EP33025
- DOI -
- Views 378
- Downloads 0
Stevia as sweetener and functional food
Regarding the daily trend of obesity incidence and increase of concerns about security of some synthesized sweetener, the requirements to non-caloric sweetener seems necessary as much as consumers’ knowledge about usin...
Formulation and characterization of superporous hydrogel of Nizatidine A MadhuSudhan Reddy*
Superporous hydrogel of nizatidine was formulated and evaluated for drug dissolution characteristics, gastric retention of the hydrogel, and drug release rate kinetics. Various excipients like Acrylamide, Acrylic acid...
Comparative in-vitro dissolution study of five brands of Diclofenac sodium delayed release tablets in QbD environment
Diclofenac sodium tablets are available as delayed release tablets in the market. Delayed release tablets are typically produced by coating the tablet with enteric coating polymers. These polymers provide the resistanc...
The Investigation of Drying on Satureja Hortensis Lamiaceae in Different Drying Treatments
The affections of different drying conditions on Satureja hortensis Lamiaceae investigated. These leaves underwent drying methods including (shadow, sun, oven (70◦C and 100◦C), and microwave). To determine the moisture...
In-vitro antimicrobial efficacy of aqueous extract of Areca nut against Enterococcus faecalis
Background and Aim: Successful root canal therapy relies on the combination of proper instrumentation and effective irrigation of the root canal system. The aim of the study was to evaluate out the antibacterial efficac...