Synthesis, characterization and antimicrobial activity of di-nitro benzil by conventional and microwave irradiation methods
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2018, Vol 5, Issue 6
Abstract
Microwave induced organic reaction enhancement (MORE) is a simple, clean, fast, efficient & economical method for the synthesis of organic molecules and has emerged as a tool towards green chemistry. Dinitro Benzil was synthesized by both conventional and Microwave-assisted method. Comparative analysis of percentage yields and total reaction time for synthesized Dinitro Benzil by both conventional method and microwave-assisted method was carried out. It was found that there is improvement in percentage yield and also drastic reduction in total reaction time, by the microwave irradiation method. Benzil is well known for their bacterial activity, so the anti-bacterial activity of synthesized Dinitro Benzil was studied by using disc diffusion method. The compound was screened for its antibacterial activity against gram positive bacteria such as Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis and gram negative bacteria such as E. coli and Pseudomonas aeruginosa. The Compound showed highest zone of inhibition against Staphylococcus epidermitis in case of gram positive bacterium and E. coli in case of gram negative bacterium compared to standard streptomycin. The activity of compound against various pathogens is mainly in a dose dependent manner that is by increasing the dose from 25, 50, 75 and 100 (μg) the activity also increases.
Authors and Affiliations
Aneesha Addanki, Rama Rao Nadendla
Keywords
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