SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL SCREENING OF NOVEL SERIES OF BIS-IMIDAZO[1,2-a]PYRIDINE DERIVATIVES
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2015, Vol 3, Issue 5
Abstract
imidazo[1,2-a]pyridine. All the synthesized compounds have been characterized by using elemental analysis, FT-IR, 1H NMR, 13C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the compounds has been checked on thin layer chromatographic plate and HPLC technique. All the synthesized compounds were tested for their antibacterial and antifungal activity (MIC) in vitro by broth dilution method with two Gram-positive bacteria, two Gram-negative bacteria and two fungal strains. The biological activities of the synthesized compounds have been compared with standard drugs Ampicillin and Greseofulvin. The compounds exhibited significant antibacterial and moderate antifungal activities. These compounds can be further exploited to get the potent lead compounds. The detailed synthesis and the antimicrobial screening of the new compounds are reported. Keywords: Imidazo[1,2-a]pyridine, Antibacterial activity, Antifungal activity.
Authors and Affiliations
Gollapalli Naga Raju| Department of Pharmaceutical Analysis Chalapathi Institute of Pharmaceutical Sciences, Guntur, India., Karumudi Bhavya Sai*| Department of Pharmacy Practice Chalapathi Institute of Pharmaceutical Sciences, Guntur, India., Jagarlamudi Rajarajeswari| Department of Pharmacy Practice Chalapathi Institute of Pharmaceutical Sciences, Guntur, India., Varanasi Vasanthi Krishna Priya, Pendyala Vandana| Department of Pharmaceutical Analysis Chalapathi Institute of Pharmaceutical Sciences, Guntur, India., Rama Rao Nadendla| Department of Pharmaceutical Analysis Chalapathi Institute of Pharmaceutical Sciences, Guntur, India.
Keywords
Related Articles
- EP ID EP1634
- DOI -
- Views 435
- Downloads 25
Formulation and evaluation of tramadol, and diclofenac sofium multimodel tablet dosage form: an overview
The current article has been focused on the unimodal pain management which are based on either central analgesic drug mechanism or non steroidal anti-inflammatory drug. These drugs control the pain by central nervous sys...
STUDIES ON PHENOTYPIC TRAITS AND GENETIC VARIABILITY IN ERG 11 GENE AMONG DRUG RESISTANT CANDIDA SPECIES
Candida is an opportunistic pathogen of human beings and other mammals. It is the leading agent of various types of diseases in immunocompromised individuals. The most common infecting species is C. albicans where as oth...
Recent applications of nanodevices
Although the "war on cancer and other disease like AIDS" is now in its fourth decade and despite much progress has been made in categorizing the environmental causes and cellular and molecular biological basis for this d...
New gingerol derivative and other related compounds from Zingiber officinale
In this article we report the isolation, characterization and evaluation of in vitro anti-colon cancer activity of a new gingerol derivative, namely (S,E)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradec-8-en-3-one, (N6),...
Screening of peripheral neuropathy among diabetic patients in urban health centre chidambaram
Background: The foot ulcers among diabetic patients are mostly neuropathic origin and therefore eminently preventable. Sensory neuropathy increases the risk of foot ulcerations by seven folds and peripheral arterial dise...