SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL SCREENING OF NOVEL SERIES OF BIS-IMIDAZO[1,2-a]PYRIDINE DERIVATIVES
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2015, Vol 3, Issue 5
Abstract
imidazo[1,2-a]pyridine. All the synthesized compounds have been characterized by using elemental analysis, FT-IR, 1H NMR, 13C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the compounds has been checked on thin layer chromatographic plate and HPLC technique. All the synthesized compounds were tested for their antibacterial and antifungal activity (MIC) in vitro by broth dilution method with two Gram-positive bacteria, two Gram-negative bacteria and two fungal strains. The biological activities of the synthesized compounds have been compared with standard drugs Ampicillin and Greseofulvin. The compounds exhibited significant antibacterial and moderate antifungal activities. These compounds can be further exploited to get the potent lead compounds. The detailed synthesis and the antimicrobial screening of the new compounds are reported. Keywords: Imidazo[1,2-a]pyridine, Antibacterial activity, Antifungal activity.
Authors and Affiliations
Gollapalli Naga Raju| Department of Pharmaceutical Analysis Chalapathi Institute of Pharmaceutical Sciences, Guntur, India., Karumudi Bhavya Sai*| Department of Pharmacy Practice Chalapathi Institute of Pharmaceutical Sciences, Guntur, India., Jagarlamudi Rajarajeswari| Department of Pharmacy Practice Chalapathi Institute of Pharmaceutical Sciences, Guntur, India., Varanasi Vasanthi Krishna Priya, Pendyala Vandana| Department of Pharmaceutical Analysis Chalapathi Institute of Pharmaceutical Sciences, Guntur, India., Rama Rao Nadendla| Department of Pharmaceutical Analysis Chalapathi Institute of Pharmaceutical Sciences, Guntur, India.
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