Abstract

Aim: Benzothiazoles and pyrazoles moieties structurally have better anti inflammatory activity. Therefore various of 8-chloro-7-fluoro-1-[4-methylphenyl] sulphonyl 1,9 dihydro[1,2,4] triazol[3,4-b][1,3] Benzothiazole containing different functional groups have been synthesized by condensing 7- Chloro-6-Fluoro-2-amino-Benzothiazole with hydrazine hydrate in the presence of ethylene glycol and conc. HCl to get 7-chloro-6-fluoro-2-hydrazinyl-1, 3-benzothiazole and then treated with potassium carbonate to get 8-chloro-7-fluoro-1,9a-dihydrol [1,2,4] triazole [3,4-b][1,3] benzothiazole and then treated with p-toulene sulphonamide in the presence of pyridine to get 8-chloro-7-fluoro-1-[4-methylphenyl] sulphonyl-1,9a-dihydro[1,2,4]triazolo[3,4-b][1,3]benzothiazole. To the above product different aromatic amines, as well as various primary and secondary amines in presence of DMF and were treated to get newly targeted compounds by replacing chlorine at 7th position. The characterization of the compounds were confirmed on the basis of their spectral (IR, 1H-NMR and MASS) data. Further, they have been screened for their anti-microbial activity. The fungal activity of the compounds was determined by means of the disc-diffusion method. The inhibition zones were measured with a caliper considering the total diameters. The antimicrobial activity of the compounds was determined by means of the disc-diffusion method.

Authors and Affiliations