The Role of Coconut Oil on Pentylenetetrazole Induced Convulsion in Rats: An Electroencephalogram Study
Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 7
Abstract
Aim: This study was carried out to investigate the role of coconut oil on pentylenetetrazole (PTZ) induced convulsant activity in Wistar rats using the laboratory model. Convulsant activity was achieved by injection of PTZ. Study Design: The rats were divided into five groups. Group 1 served as control and received distilled water orally. Group2 was a reference group and received only PTZ. The remaining three groups (3, 4 and 5) were test groups and rats were given oral administration of coconut oil at doses of 2, 4 and 5.3 ml/kg for 21 days. Methodology: 25 rats weighing between 125 and 200g were used. 30 minutes after the last administration of coconut oil after 21 days, a convulsive dose of PTZ was given intraperitoneally. Electroencephalogram (EEG) readings of the rats were then taken using an EEG machine and electrodes placed on the head of the rats recorded the waves produced on the scalp of the rats. The frequencies of the waves recorded were analyzed and compared for all groups. Result: The frequency of EEG readings produced during convulsion that was caused by the PTZ in the rats were reduced for the rats that received coconut oil. There was a significant decrease in the mean frequency of EEG of rats that received 2, 4 and 5.3 ml/kg coconut oil ( which had frequencies of 13Hz, 14.6Hz and 14. 4Hz, respectively) when compared with the reference group that received only PTZ which had a mean frequency of 16Hz. Coconut oil significantly reduced the frequency produced by PTZ. The result also shows that the lower dose group had the most appreciable decline in convulsive activity returning the frequency of electroencephalogram waves recorded to 13Hz same as the control group. Conclusion: The result suggests that coconut oil given at a moderate dose has anticonvulsant effect and will cause an increase in weight. These findings supports reports that ketogenic diet could help reduce convulsant activities and epileptic seizures.
Authors and Affiliations
Meraiyebu Ajibola, Olugbemi Olaniyan, Oshimakinde Abiola, A. Seriki Samuel, Okere Shekins
Keywords
Related Articles
- EP ID EP344955
- DOI 10.9734/BJPR/2014/4978
- Views 115
- Downloads 0
Determination of Survival Rates of Bacteria in Contaminated Fresh Fruit Juice Samples
Aims: To determine the survival rates of bacteria in contaminated fresh fruit juice samples Place and Duration of Study: Biosciences and Biotechnology Department, Babcock University, Ilisan Remo, Ogun State, Nigeria, bet...
Efficacy Appraisal of Some Antidiabetic Herbal Preparations Available in Bangladesh
Antidiabetic Herbal Preparations (ADHP) are being used for the management of diabetes mellitus (DM) but their efficacy in controlling hyperglycemia is not scientifically evaluated. This study was undertaken to evaluate t...
Isolation, Characterization and Antimicrobial Activity of 3β, 22E-Stigmasta-5, 22-dien-3-ol from the Aerial Part of Aeschynomene uniflora E. Mey
Objectives: To isolate, characterize and determine the antimicrobial activity of bioactive compounds present in the petroleum ether fraction of the aerial parts of Aeschynomene uniflora E. Mey. Methods: Aeschynomene unif...
Investigations into Antibacterial, Phytochemical and Antioxidant Properties of Vitellaria paradoxa (Gaertn.) Stem Bark Extracts
This study investigated the antibacterial potentials and mechanisms of action of crude extract and fractions from stem bark of Vitellaria paradoxa on susceptible bacterial isolates. It also assessed the phytochemical con...
Determination of Vitamin B6, B9 and B12 in Halophytes by Solid Phase Extraction Followed by HPLC-UV
In this work, solid phase extraction (SPE) was proposed for simultaneous determination of trace levels of vitamin B6, B9 and B12. High performance liquid chromatography with UV detection (HPLC-UV) was used. The experimen...