Therapeutic hypothermia with Whole Body Cooling and its Adverse Effects in Newborns with Perinatal Asphyxia
Journal Title: International Research Journal of Applied and Basic Sciences - Year 2013, Vol 5, Issue 9
Abstract
Hypothermia is the most promising therapy care in infants with birth asphyxia. However during cooling period brain temperature fluctuation leads to cerebral edema and subsequently adverse effects on hemodynamic status and brain development. Therefore, this study conducted aim to determine side effects of hypothermia during cooling period in newborns with perinatal asphyxia. This is a descriptive- analytical study in which 25 infants with birth asphyxia were selected using census method from a teaching hospital affiliated with Tabriz University of Medical Sciences. These babies underwent topical head cooling up to target rectal of 32.5- 33.5 °c temperature. They remained in this temperature for 72 hours and then it was gradually increased during 8-12 h to 36.5 °c. During the cooling period possible short term side effects were observed and mortality was assessed. Data was analyzed using SPSS/17 and descriptive (mean, standard deviation, number, percent) and repeated ANOVA statistics. According to the findings the mean time to cool newborns was 4.7± 1.8 hours after delivery while temperature fluctuation was about 0.41°c. Meanwhile seizure (n=21, 84%) and pulmonary hemorragia (n=3,12/%) were respectively the most and the least common short time side effects. Findings showed reduction in both frequency of incidence of side effects and newborns’ mortality during the intervention. Thus hypothermia can be one of the most effective therapeutic approaches to increase survival rate and quality of life of infants with birth asphyxia.
Authors and Affiliations
Assadollahi M| MS in Pediatric Nursing, Faculty Member of Nursing and Midwifery School, Tabriz University of Medical Sciences, Arshadi M| Student of Nursing Education, Faculty Member of Nursing and Midwifery School, Tabriz University of Medical Sciences, Jannatdoost A| PhD in Biostatistics, Assistant Professor, Faculty member of Tabriz University of Medical Sciences, Mohammadi F| MS Student Neonatal intensive care nursing, Nursing and Midwifery School, Tabriz University of Medical Sciences
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