Toxicity Studies of Combined Extracts of Acalypha hispida, Acalypha nervosa Acalypha fruiticosa
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 4
Abstract
The present investigation was carried out to evaluate the safety of methanolic extract from leaves by determining its potential toxicity after acute and sub acute administration in mice. For the acute study, Combined extracts of Acalypha hispida Acalypha nervosa Acalypha fruiticosa was administrated to mice in single doses given by oral route. General behavior adverse effects and mortality were determined up to7 days. In the Sub acute study, the extract was administered orally at doses of 200 and 400 mg/kg for 28 days to mice Biochemical and hematological parameters were determined at the end of 28 days of daily administration. The studies on sub acute toxicity reveals that no mortalities or evidence of adverse effects have been observed in mice following acute oral administration at the highest dose of 2000mg/kg crude extracts of Acalypha hispida Acalypha nervosa Acalypha fruiticosa . In sub acute toxicity study daily oral administration of methanolic extracts of 200 and 400 mg/kg body weight of Combined extracts of Acalypha hispida Acalypha nervosa Acalypha fruiticosa for up to 28 days did not result in death or significant changes in body weight, Hematological and Biochemical parameters were done and tabulated.
Authors and Affiliations
K Bhargava Manikanta, P Raghu Varma, P Vamsi Krishna, A Ravi Kumar, K M Subbu Rathinam
Keywords
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