Transfusion-associated necrotizing enterocolitis (TANEC) – early post-transfusion complication in neonates with extremely low birth weight (ELBW) or one of the risk factor necrotizing enterocolitis (NEC)? One centre’s experience
Journal Title: Postępy Nauk Medycznych - Year 2015, Vol 28, Issue 11
Abstract
Introduction. Necrotising enterocolitis (NEC) is a disease developing in neonates.In extreme cases, the septic necrosis of the intestine wall can cover the entire thicknessof its wall and result in intestine perforation and, in consequence, to peritonitis. Transfusionof packed red blood cells (RBCs) is indicated as a NEC onset predisposing factor,possibly resulting in development of the disease unit referred to as TANEC (transfusion--associated NEC) in 48 hours upon transfusion. The noted TANEC cases caused a moreserious course than in case of NEC and in most cases they required a lifesaving surgicalintervention and were connected with high death rate. Neonates with TANEC are moreprobable to undergo a lifesaving surgical intervention than neonates with NEC in whomno RBCs were transfused.Aim. Gathering data from the literature and our own experience associated with NECand analysis, whether TANEC can be considered as a new early post-transfusion complicationsthat occurs in premature infants with ELBW.Material and methods. The analysis covered medical documentation and laboratorytest results in order to explain the reasons for post-transfusion complications in a 3-monthsold female neonate.Results. Based on the data from literature and upon analysis of the described case,one can pose the following question: can TANEC be deemed the new early post-transfusionreaction in preemies with ELBW?Conclusions. TANEC can be deemed the new early post-transfusion reaction in preemieswith ELBW. Determination of such a cause and effect relation requires performanceof further research and clinical analysis on a greater number of patients.
Authors and Affiliations
Aleksandra Janusz, Joanna Janusz, Krystyna Wieczorek, Anna Grajewska, Maria Czachura, Bożena Drybańska
Keywords
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