Transfusion reactions in 711 pediatric patients: a retrospective analysis
Journal Title: Chinese Journal of Blood Transfusion - Year 2024, Vol 37, Issue 6
Abstract
Objective To analyze the characteristics and related influencing factors of transfusion reactions in pediatric patients, so as to provide evidence for clinical treatment and prevention of transfusion reactions. Methods A retrospective study was conducted on children who received blood transfusions at our hospital from 2019 to 2023 in terms of the incidence, types, time of occurrence, and related influencing factors of transfusion reactions. Results A total of 69 926 transfusions were performed from 2019 to 2023, with 711 cases of transfusion reactions, resulting in an incidence of 1.02%. The incidence of transfusion reactions decreased annually from 2019 (1.89%) to 2022 (0.50%). The incidence of transfusion reactions to apheresis platelets, frozen plasma, suspended leukocyte-depleted red blood cells and cryoprecipitate coagulation factor were 2.16% (551/25 565), 0.50% (92/18 277), 0.25% (65/25 679) and 0.74% (3/405), respectively, with apheresis platelet transfusion of a significantly higher incidence compared to other blood components (P<0.05). As of transfusion reaction types, allergic reactions accounted for 86.22% (613/711), febrile non-hemolytic transfusion reactions (FNHTR) accounted for 13.08% (93/711), and acute hemolytic transfusion reactions accounted for 0.70% (5/711). Multivariate logistic regression analysis showed that apheresis platelet transfusion was an independent risk factor for allergic reactions (P<0.05), while suspended leukocyte-depleted red blood cells transfusion was an independent risk factor for FNHTR (P<0.05). In terms of the occurrence time of transfusion reactions, compared to apheresis platelets and frozen plasma, transfusion reactions caused by suspended leukocyte-depleted red blood cells transfusion occurred later (apheresis platelets P<0.05, frozen plasma P<0.05). Conclusion The results suggest that blood components transfused are significant influencing factors for the characteristics of transfusion reactions in pediatric patients, affecting the incidence, types, and occurrence time of transfusion reactions, which provides reference for clinical treatment and prevention of transfusion reactions.
Authors and Affiliations
Hongyu FU, Zhichen ZHU, Li FENG, Yuqing GAO, Jing LING
Keywords
Related Articles
- EP ID EP742787
- DOI 10.13303/j.cjbt.issn.1004-549x.2024.06.012
- Views 19
- Downloads 0
Construction of a rapid depression screening model for blood donors in Guangzhou based on decision tree
Objective To investigate the prevalence of depression in blood donors and analyze the related factors, so as to develop a rapid depression screening model for blood donors. Methods A total of 13 015 street whole blood do...
Changes of cryoprecipitate coagulation factors prepared by different preparation methods and quick-freezing time
Objective To analyze the changes of fibrinogen (Fg) and Ⅷ factor levels of cryoprecipitated coagulation factors prepared by different methods and post-preparation quick-freezing time. Methods The fresh frozen plasma (FFP...
Study on the hepatitis B virus infection in blood donors reactive to jointed NAT but non-reactive to primary discriminatory test
Objective To analyze the status of HBV infection in blood donors reactive to jointed NAT but non-reactive to primary discriminatory tests (NRR), so as to provide suggestions and data support for subsequent studies on NRR...
Correlation between unexpected antibody types and transfusion efficacy in patients with autoimmune hemolytic anemia (AIHA)
Objective To analyze the antibody types of autoimmune hemolytic anemia(AIHA) patients in Panyu district, Guangzhou and track the therapeutic effect of blood transfusion, so as to provide reference for clinical transfusio...
Correlation between heart rate variability and psychological evaluation before blood donation
Objective To investigate the correlation between heart rate variability (HRV) and the degree of nervousness before blood donation. Methods The psychological state of 253 blood donors before blood donation was assessed by...