Utilization of Ondansetron and Dexamethasone for Post-Operative Nausea and Vomiting (PONV) after Laparoscopic Cholecystectomy at Bhuj, Kutch, Gujarat: A Randomised Control Trial
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2017, Vol 4, Issue 2
Abstract
Background and Aim: Postoperative nausea and vomiting still occur with unacceptable frequency and the description of it as the ‘Big Little Problem’ encapsulates much of the general perception. The incidence is quite high even after laparoscopic surgeries including gall bladder surgeries. Present study was conducted to assess the level of PONV following laparoscopic cholecystectomy and the effect of dexamethasone and ondansetron, individually on PONV following laparoscopic cholecystectomy. Materials & Methods: The study was conducted at Department of Anesthesia Gujarat Adani Institute of Medical Science, Bhuj, Kutch, Gujarat. 60 patients presenting for elective laparoscopic cholecystectomy were randomised to 3 groups. Group 1 as control, group 2 received dexamethasone and group 3 received ondansetron for PONV prophylaxis. All three groups were evaluated for incidence of postoperative nausea and vomiting. Comparison of the observation among different groups was done and statistically analyzed using Fisher’s exact test and MannwhitneyU test. Results: The incidence of PONV was 50% in the control group, compared to 12% in the dexamethasone group and 22% in the ondansetron group during the first 24 hours. At 1 hour the total incidence of PONV was 85% in control group, 30% in dexamethasone group and 25% in ondansetron group. At 4 hours the total incidence of PONV was 60% in control group, 5% in dexamethasone group and 15% in ondansetron group. The incidence of PONV at 8 hours was 55% in control group, 10% in dexamethasone group and 40% in ondansetron group. Conclusion: The incidence of PONV following laparoscopic cholecystectomy is high and both dexamethasone and ondansetron effectively reduce the incidence of PONV in these patients.
Authors and Affiliations
Mandakinee Thacker
Keywords
Related Articles
- EP ID EP464692
- DOI 10.21088/ijaa.2349.8471.4217.6
- Views 106
- Downloads 0
Awake Fiberoptic Intubation with Two Different Techniques of Local Anaesthetic Administration (Transtracheal Injection Versus Ultrasonic Nebulization) in Patients Undergoing Maxillofacial Surgery
Background and Aims: Awake fiberoptic intubation (AFOI) is considered the gold standard for anticipated difficult intubation in maxillofacial surgery. Regional anaesthesia of the airway is essential for awake fiberoptic...
A Comparative Evaluation of Dexmedetomidine and Midazolam in Monitored Anaesthesia Care for Tympanoplasty
Introduction: Monitored Anaesthesia care (MAC) has been defined by the American Society of Anaesthesiologists as a diagnostic or therapeutic procedure done under local anaesthesia along with sedation and analgesia. Advan...
Comparison between Trapezius Squeezing Test and Jaw Thrust as Indicators for Proseal Laryngeal Mask Airway in Paediatric Patients: A Single Blind Prospective Study
Aim: Present study was carried out to compare the efficacy of trapezius squeeze test and jaw thrust as clinical tests to indicate an adequate depth of anaesthesia for insertion of the Proseal laryngeal mask airway after...
Assessment of Sensory and Motor Blockade by Bupivacaine with Dexmeditomedine or Fentanyl as Adjuvant in Lower Abdominal and Lower Limb Surgeries
Introduction: In the present-day practice of Anaesthesiology Bupivacaine is the most commonly used drug for subarachnoid block. Many adjuvants have been tried to improve the quality of analgesia and to prolong the durati...
Postoperative Analgesia for Inguinal Hernia Repair: Comparison of Ropivacaine with Bupivacaine
Background and Objectives: Inguinal hernia surgery is one of the commonest day care procedures and have very high incidence of moderate to severe postoperative pain which remains a great challenge for the anesthesiologis...