Wilms' tumor: A systematic review
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2014, Vol 31, Issue 1
Abstract
Wilms' tumor (nephroblastoma) is a malignant embryonic tumor of the kidney, accounting for 6% of childhood malignancies. It has been the epitome of multi-specialty treatment of a pediatric solid tumor, which has led to radical improvement in its prognosis. Today's knowledge is based mainly on the results of the clinical trials conducted by two groups: The National Wilms' Tumor Study Group (NWTS) in the USA and the International Society of Paediatric Oncology (SIOP) in Europe. The SIOP studies used preoperative treatment followed by nephrectomy, while the NWTS approach was immediate nephrectomy and adjuvant treatment. In the past, with surgical resection only, the survival rates were 20−40%. Today 80−90% of the patients is cured. The prognosis is affected by the stage and histology of the tumor and by a series of newly described genetic factors.
Authors and Affiliations
N. KOSMAS
Keywords
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