Asian Pacific Journal of Health Sciences

Asian Pacific Journal of Health Sciences

Basic info

  • Publisher: IJPMR Publishing Press, India.
  • Country of publisher: india
  • Date added to EuroPub: 2019/Sep/29

Subject and more

  • LCC Subject Category: Medicine, Health and Wellness
  • Publisher's keywords: Medicine, Health
  • Language of fulltext: english
  • Time from submission to publication: 6 weeks

Publication charges

  • Article Processing Charges (APCs): No
  • Submission charges: No
  • Waiver policy for charges? No

Open access & licensing

  • Type of License: CC BY
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2014
  • Does the author retain unrestricted copyright? False
  • Does the author retain publishing rights? False

Best practice polices

  • Permanent article identifier: DOI
  • Content digitally archived in: Other
  • Deposit policy registered in: None

This journal has '459' articles

Anaesthesia for anterior chamber wash-out andcorneo-scleral repair in a patient with hypertensive heart disease: A case report

Anaesthesia for anterior chamber wash-out andcorneo-scleral repair in a patient with hypertensive heart disease: A case report

Authors: Onyegbule Okubuiro Eze
Year: 2018, Volume: 5, Number: 4
(0 downloads)
Abstract

AO, a 48-year-old police officer with poorly controlled hypertension and previous myocardial infarction was referred from a peripheral hospital to University of Port Harcourt Teaching Hospital (UPTH), Port Harcourt, Nigeria on account of gunshot injury to the right eye. His blood pressure was 180/120 mmHg. The electrocardiogram (ECG) showed evidence of previous inferior myocardial infarction (MI) and 1st degree right bundle branch block. Emergency anterior chamber wash out and repair of corneo-scleral laceration was deferred for twenty-four hours to allow successful control of hypertension. The surgical procedure was finally performed under general anaesthesia with endotracheal intubation and muscle relaxation. Intraoperatively, patient developed few ventricular ectopic beats which resolved spontaneously. He had uneventful postoperative recovery and was discharged home on the 12th postoperative day. This report discusses anaesthetic challenges associated with hypertensive heart disease patients requiring emergency surgery in a resource limited setting.

Keywords: Anaesthesia, corneo-sclera, repair, hypertensive, heart-disease.
Clinicoimmunological Study of Autoimmune Hepatitis

Clinicoimmunological Study of Autoimmune Hepatitis

Authors: Sharma P
Year: 2018, Volume: 5, Number: 4
(0 downloads)
Abstract

Auto immune hepatitis is associated with characteristic autoantibodies and hypergammaglobulinemia. The aim of study is to see prevalence of various types of AIH. Material and Method: Study included 66 cases of AIH, 16 cases of chronic viral hepatitis (8 hepatitis B, 8 hepatitis C) and 18 healthy control between a period of 1.5 years. Antinuclear antibody (ANA), anti-mitochondrial antibody (AMA), anti smooth muscle antibody (ASMA), anti F-actin antibody, anti parietal cell antibody were done by indirect fluorescent method (IIF) on frozen section of rat liver, stomach, and kidney. It was also done by immunodot method. ANA was repeated by ELISA technique. Result: AIH-1 formed maximum cases (89.39%) followed by AIH-2 (9.09%) and AIH-3 (1.51%). In AIH-1 23.7% and in AIH-2 66.66% were children. Male predominance was in AIH-1 (59.3%).Weakness, loss of appetite, weight loss and jaundice were common in more than 86% patients in all types of AIH. Ascitis was more common in AIH-1 (61%) than in AIH-2 (33.3%). ASMA antibody was positive in all cases of AIH-1 while anti LKM was positive in AIH-2. ANA was positive in 16.9% cases of AIH by IFT method and 30.54% by ELISA. APCA was positive in 27% cases. Two cases each of AIH-1 were positive for AMA, endomysium, anticentromere, anti Smith, anti RNP and anti-laminin antibody. All AIH-1 and AIH-2 cases had significantly elevated transaminases, bilirubin, alkaline phosphatase and serum IgG. Thus, our study concludes that AIH1 is more common than AIH2 and ASMA is more common antibody.

Keywords: Autoimmune hepatitis, autoimmune liver disease, chronic hepatitis, anti smooth muscle antibody, anti Factin antibody, anti LKM antibody, anti soluble liver antigen antibody.
Common Sleep Disorders and Risk Factors in Hemodialysis Patients

Common Sleep Disorders and Risk Factors in Hemodialysis Patients

Authors: Emine DERYA ISTER
Year: 2018, Volume: 5, Number: 4
(0 downloads)
Abstract

Although the function and physiology of sleep have not been fully elucidated, it is a universal need for life-forms such as human beings, and in the absence of sleep, severe physiological consequences emerge. Sleep can be defined as temporary, partial and periodic disappearance of the organism’s communication with the environment and it is reversible with various severity stimuli. Sleep disorders in hemodialysis patients are frequently seen with the contribution of various risk factors. Insomnia is the most common sleep disorder in hemodialysis patients and affects the sleep quality of patients negatively. Insomnia is a lack of adequate and restful sleep despite adequate reserved time to sleep and it refers to sleeplessness. Sleeplessness can be defined as difficulty in starting sleep, and it refers insufficiency in duration, integrity and quality of sleep despite there is adequate time and chance to sleep. Anemia, anxiety, depression and many factors cause sleep disorders in hemodialysis patients. The aim of this review is to give information about the prevalence of common sleep disorders in hemodialysis patients and the risk factors that contribute to the development of these disorders.

Keywords: Hemodialysis, Sleep Disorder, Risk Factor, Prevalence, Patient.
At what rate does advanced age affect decision-making on neoadjuvant therapy?

At what rate does advanced age affect decision-making on neoadjuvant therapy?

Authors: Muhammed Üçüncü
Year: 2018, Volume: 5, Number: 4
(0 downloads)
Abstract

Introduction: Increasing numbers of patients with breast cancer receive neoadjuvant therapies. We investigated differences in survival rates between geriatric and non-geriatric patient groups following administration of neoadjuvant therapies. Materials and Method: We examined 166 patients who received neoadjuvant therapy for breast cancer between 2007 and 2016. Patients <70 years were in Group 1 and those ≥70 years were in Group 2. We retrospectively compared age, sex, treatment, tumour stage and localisation, status of oestrogen and progesterone receptors, involvement of axillary lymph nodes, systemic treatment complications, treatment compliance and survival rates using a variety of parametric and non-parametric statistical tests. Results: The mean ages of patients in Group 1 [n = 136] and Group 2 [n = 30] were 44.6 ± 8.92 and 76.7 ± 5.48 years, respectively. The most common tumour location was the upper-outer quadrant. All patients received treatment consisting of 4AC [doxorubicin-cyclophosphamide] + 4 taxane or 4AC [doxorubicin-cyclophosphamide] + paclitaxel for 12 weeks. Neither group exhibited mortality or complications requiring treatment interruption. Breast-conserving surgery was performed in 88 [53%] patients. Complete response was achieved in 14 [8%] patients after surgery. Mean tumour diameters in Groups 1 and 2 were 26.8 mm [±27.59] and 28.5 mm [±40.23], respectively. Five-year general survival rates were % 69,7 in Group 1 and % 70 in Group 2[ p = 0.94]. Conclusion: Neoadjuvant therapy is a reliable treatment option in patients ≥70 years who are candidates for chemotherapy, since complication and mortality rates did not increase compared with younger patients.

Keywords: Geriatry, breast cancer, neoadjuvant therapy; mortality.
Preliminary Phytochemical Studies, Evolution of antimicrobial and in vitro cytotoxic studies of selected polyherbal mixture of dietary importance

Preliminary Phytochemical Studies, Evolution of antimicrobial and in vitro cytotoxic studies of selected polyherbal mixture of dietary importance

Authors: Gunji Venkateswarlu
Year: 2018, Volume: 5, Number: 4
(0 downloads)
Abstract

Background: In the present study we were evaluated pharmacognostical; antimicrobial and cytotoxic studies of the aqueous and Ethanolic extracts of the dietary polyherbal powders because they are great importance in the treatment of various metabolic disorder. Materials and methods: the following powder mixtures of Malus pumiplus (fruit), Momordica chirata (fruit) powder, Citrus limon (fruit), Pleurotus ostreatus (Mushroom), and Triticum aestivum (wheat grass) were extracted with distilled water and with ethanol. Results and conclusion: The result indicates that the above solvents having better extractive values with good bioactive components like Polyphenols, Glycosides, and Saponins. These are responsible bioactive phytochemical used in the herbal therapy. The aqueous and the Ethanolic were evaluated for The anti-microbial activity by cup plate method and the diameter of zone of inhibition is nearly equal to the standard drug and both the extracts showed potential cytotoxic activity through the in-vitro cytotoxic studies by MTT assay.

Keywords: Dietary powders, preliminary phytochemicals, antimicrobial, in-vitro MTT assay.
Design and development of chronomodulated pulsincap delivery system of deflazacort

Design and development of chronomodulated pulsincap delivery system of deflazacort

Authors: Binu Raina
Year: 2018, Volume: 5, Number: 4
(0 downloads)
Abstract

Aim of the present study was to formulate, evaluate and optimize the Pulsincap delivery system of deflazacort used in rheumatoid arthritis, based on the chronotherapeutic approach. The prepared pulsincap system consist of immediate release tablet sealed inside formaldehyde treated insoluble capsule body by hydrogel plug composed of polymer HPMC K15M and sodium alginate. Our target was to formulate a delivery system that could release the drug as per chronotherapeutic pattern of the disease (rheumatoid arthritis), so preliminary batches were prepared to study the effect of concentration of HPMC K15M and sodium alginate on the lag time of the drug release. Optimization of hydrogel plug was carried out by employing 32 full factorial design using Design expert 7 Software. The optimized batch of pulsincap sytem was found to release after a lag time of 366.66±2.887 minutes.

Keywords: Chronothepary, Deflazacort, Rheumatoid arthritis, Pulsincap, 32 Full factorial design.
Uropathogenic Escherichia coli: Correlation between virulence factors and serotypes

Uropathogenic Escherichia coli: Correlation between virulence factors and serotypes

Authors: K.P. Ranjan
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

Background: Urinary tract infections (UTIs) are the most commonly encountered bacterial infections both in community and health-care settings. Objective: We determine the prevalence of virulence factors and serotypes associated with uropathogenic Escherichia coli (UPEC). In addition, we also compare the possible relationship between virulence factors with serotypes. Materials and Methods: A total of 200 E. coli isolates were collected from clinically suspected UTI and detection of virulence factors such as hemolysin production, hemagglutination, biofilm formation, and also serotyping was done. Results: The incidence of UTI was more in the age group of 21–30 years and more in females. Hemolysin production was seen in 23% strains. Hemagglutination was shown by total 127 (63.5%) isolates. One hundred nine (54.5%) isolates showed production of moderate and high-value biofilms. Among the serotypes, O1, O2, O8, O90, O101, and O125 were the most commonly isolated uropathogens. Among all the serotypes of UPEC isolates, maximum hemolysin production and hemagglutination were seen in O8 serotype. Conclusion: Certain serotypes of UPEC are more commonly associated with UTI. These serotypes have a wide array of virulence factors and their identification may facilitate the application of more precise approaches in diagnosis of UTIs

Keywords: Biofilm, serotype, urinary tract infections, uropathogenic Escherichia coli, virulence factors
Assessment of sleep quality/quality of life and affecting factors ın nurses working ın child ıntensıve care unıt

Assessment of sleep quality/quality of life and affecting factors ın nurses working ın child ıntensıve care unıt

Authors: Özsoylu Serkan
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

Background: Insomnia, deterioration of sleep rhythm, deterioration of sleeping integrity, and involuntary movements in sleep impairs the life quality of nurses and also negatively affects working efficiency. Aim: We aimed to evaluate the complaints of sleep disorders with both subjective and objective tests among nurses working in the intensive care unit and compare these complaints with nurses working in policlinic and other services. Study Design: This was a cross-sectional study. Methods: The study was designed a cross-sectional study on nurses working at University Medical Faculty between April and May 2017 using different forms. The bivariate and partial correlation tests were used to analyze the correlations between parameters. Univariate and multiple binary logistic regression analyses were performed to estimate influencing effects of multiple variables on beck depression scale (BDS), Epworth sleepiness scale, and Pittsburgh sleep quality index scales. A two-sided P < 0.05 was considered statistically significant. Results: Among the 44 shift-working nurse participants, 31.8% were 25–29 years old, 31.8% were 30–34 years old, 13.6% were 35–39 years old, and 22.8% were ≥40 years old. Their average age was 30.5 years old. (min: 22 - max:46) In our study, BDS score of the nurses working in pediatric intensive care unit was higher than the nurses working in service and polyclinics. (P < 0.01) In addition, intensive care nurses can be said to be more stressful than other units because of the need for emergency intervention and precise follow-up and the presence of more patients and workload. We found that nurses working in the ICU are significantly more sleepy than nurses on the floor. Among nurses, current or previous night work experience was associated with more caseness of insomnia than no night work experience. Conclusion: It should be taken into consideration that the service provided by health personnel may affect human health very seriously. Therefore, this issue should be approached in consideration of how seriously the performance of sleep disorders will affect their performance.

Keywords: Beck depression scale, nurse, pediatric intensive care unit, sleep quality
Age, gender, and voided volume dependency of peak urinary flow rate and uroflowmetry nomogram in a tertiary care centre

Age, gender, and voided volume dependency of peak urinary flow rate and uroflowmetry nomogram in a tertiary care centre

Authors: Pushpendra Malik
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

Uroflowmetry is a simple, diagnostic screening procedure used to calculate the flow rate of urine over time. The measurement of urine flow by uroflowmetry is non-invasive and is the easiest urodynamic test useful as preliminary or follow-up investigation of the lower urinary tract symptoms. Introduction: Uroflowmetry is a non-invasive test used to assess bladder and sphincter function. Even though uroflowmetry is not specific in identifying outlet obstruction, the flow rate remains an extremely sensitive indicator of lower urinary tract symptoms..Here the amount of urine, rate of flow in seconds, and length of time is calculated until completion of the void and this information is converted into a graph and interpreted by a urologist. The information helps to evaluate function of the lower urinary tract or help determine obstruction of normal urine outflow. Materials and Methods: The present study was conducted on 5 groups of people attending the emergency surgical ward and OPD at a tertiary care centre from Jan 2011 to Oct 2012 who were analyzed separately and intergroup differences were statistically studied.l Nomograms were presented in centile form and prepared for each group. The difference was assessed for significance using a student’s t- test. Nomograms were constructed depicting the normal Gaussian distribution of maximum and average urinary flow rate at volumes ranging from 50 to 1000 cc.. Evaluated parameters were voided volume, maximum flow rate, average flow rate, flow time, and time to Qmax Results: Maximum flow rate (Qmax) is more significantly correlated with age and voided volume than average flow rate (Qavg); hence, Qmax is the single most useful parameter of uroflowmetry.Qmax increases with age in the paediatric population and decreases with age in the adult and elderly population.Qmax in girls was significantly higher than in boys.Nomogramsin centile form can be constructed to provide normal reference ranges for urinary flow rates covering a wide range of voided volumes

Keywords: Uroflowmetry, voided volume,nomograms
Impact of health care on geriatric population and need for adult day care centers - a cross-sectional study of
Kerala population

Impact of health care on geriatric population and need for adult day care centers - a cross-sectional study of Kerala population

Authors: Vidya Jha
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

Background: According to the World Health Organization, proportion of the world’s population over 60 years is expected to double from about 12% to 22% between 2015 and 2050. When compared to 42.34% increase in the working population in India, the increase in number of elderly was found to be higher at 54.77% in the past 15 years. Poor understanding of elderly life in India has led to a weak care and support system for them. Aims and Objectives: The present study aims to find the feasibility of starting an Adult Day Care Center (ADC) in the study area, find the cost of hospitalization for the elderly and also the cost of starting an ADC by proposing an ideal model of an Adult Healthcare Center. Methods: The study was conducted in Kanayannur taluk of Ernakulam district. Using simple random sampling, 398 elderly people above the age of 60 years were interviewed using a structured questionnaire to understand their morbidity issues and corresponding cost of care. Assessment of quality of life, disease burden and health-care expenditure and acceptance of ADC was done. Results: The study included 205 (52%) males and 193 (48%) females. 60% of the elderlies had single/double/triple illness. 46% of elderly people were keen to join the proposed ADCs. There was a significant correlation between cost of hospitalization and diabetes, hypertension, and high cholesterol levels. Conclusions: The study clearly indicates the need for a comprehensive policy on geriatric patients in Kerala and the need for setting up dedicated ADCs.

Keywords:
Are nurses creative?

Are nurses creative?

Authors: Y Çevik Durmaz
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

Creativity is the ability to imagine something that is not exist, to do something different from others, and to develop new ideas. In other words, creativity is to see something as everyone sees it and to think about different things about it. A health-care system that incorporates many threats and problems forces nurses to find effective and creative solutions. It is a recognized fact that nurses who play an important role in the health-care sector and who directly influence patient care quality, hospital productivity, and image are creative. Nurses are able to use existing resources in a very different and original way by means of their creative thinking skills in the problems they face during the patient care process, and they are able to produce new solutions that do not exist for the problem. Nurses must be supported both institutionally and administratively to be: “Creative.” In the education process, creativity should be developed with interesting and motivational activities. The nurses who have developed creativity will find creative and practical solutions that can cope more easily with the crisis situations in the health-care environment where the changes and competition are increasing. In the field of creativity in nursing, there are many examples from past to present,both domestic and abroad.

Keywords: Creative thinking, creativity, nurse
Pre-and post-dialysis hematological indices of patients
with chronic kidney diseases attending dialysis center
of a tertiary hospital in Yola, Nigeria

Pre-and post-dialysis hematological indices of patients with chronic kidney diseases attending dialysis center of a tertiary hospital in Yola, Nigeria

Authors: Idris Abdullahi Nasir
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

Background: Hemodialysis (HD) is the most common modality for renal replacement treatment in Sub-Saharan Africa where near normal kidney function is achieved in most patients with chronic kidney disease (CKD). Objective: This case–control study sought to determine hematological changes and to compare the level of these changes in predialysis and post-dialysis stages in patients with CKD attending the dialysis unit of federal medical center, Yola, Nigeria. Materials and methods: A total of 100 kidney disease patients were used as study subject while 50 individuals without kidney disease were used as control group. All hematological parameters comprising packed cell volume (PCV), hemoglobin concentration (Hb), platelets count, red cell indices (mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular Hb concentration), and differential leukocyte count were analyzed using standard methods as provided by five parts Beckman oulter hematology auto analyzer. Results: The highest proportion (29%) was observed at age group, 51–55 years and least (1%) in those 76–80 years. The mean age of male HD patients was 56.9 ± 2.7 years while that of female was at 42.5 ± 6.2 years and the male to female ratio in HD patients was 2.6:1. The patients at pre-dialysis have significantly reduced mean ± standard deviation of Hb concentration (6.3 ± 1.8 g/dl), red blood cell (RBC) count (2.1 ± 1.3 × 106 /ul), and platelet count (186 ± 28.2 × 103 /ul) compared to control group which had 12.2 ± 1.4 g/dl, 4.4 ± 0.2 × 106 /ul, and 350.5 ± 82.2 × 103 /ul, respectively; while in contrast had higher lymphocyte count (39.7 ± 3.0%) when compared with the control group (37.0 ± 4.2%). At post-dialysis stage, PCV (27.1 ± 5.0%), Hb concentration (7.8 ± 1.2 g/dl), RBC count (2.9 ± 0.5 × 106 /ul), and neutrophil (58.3 ± 3.8%); significantly increased compared with pre-dialysis stage with PCV (24.1 ± 2.0%), Hb concentration (6.3 ± 1.8 g/dl), RBC count (2.1 ± 1.3 × 106 /ul), and neutrophil (54.7 ± 3.2%). Conclusion: There is a remarkable improvement in hematological indices in CKD patients undergoing maintenance HD.

Keywords: Hemodialysis, hematological indices, kidney disease
Outcome of dacryocystectomy with nasal bone
osteotomy for lost nasal flap dacryocystorhinostomy
with repeated post-operative probing

Outcome of dacryocystectomy with nasal bone osteotomy for lost nasal flap dacryocystorhinostomy with repeated post-operative probing

Authors: Pavana Acharya
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

Aim: (1) To evaluate the effect of dacryocystectomy (DCT) with osteotomy on correction of epiphora in terms of subjective and objective assessment and (2) to compare the outcome of probing with non-probing in DCT with osteotomy. Materials and Methods: A prospective interventional study done on 36 patients with chronic dacryocystitis complaining of watering due to distal sac block or nasolacrimal duct block with intraoperative complications like significant bleeding when angular vessels are encountered, difficult in suturing flaps, or lost nasal flaps are subjected to the study from December 2015 to May 2017. DCT with nasal bone osteotomy done for these patients and they were followed up postoperatively on day 1, every week in the 1 st month, 2 weeks in the 2nd month, and once in the 3rd month with probing or without probing in randomly selected patients. Results: A total of 36 patients were subjected to DCT with nasal bone osteotomy among them 18 underwent for probing and 18 were not. Of 18 with probing patients, 4 (22%) were objectively corrected (no regurgitation on lacrimal syringing) and 8 (44%) were subjectively corrected (no complaints of watering). Of 18 non-probing patients, only 1 (5.5%) was corrected objectively and 2 (11%) were corrected subjectively. Conclusion: DCT with nasal bone osteotomy with probing is more effective when compared with non-probing in lost nasal flap dacryocystorhinostomy both in terms of subjective and objective correction of epiphora.

Keywords: Dacryocystitis, dacryocystorhinostomy, lacrimal probing, nasal bone osteotomy
Ethnomedicinal value and pharmacognosy of the
member of Acanthaceae: Adhatoda vasica (Linn.)

Ethnomedicinal value and pharmacognosy of the member of Acanthaceae: Adhatoda vasica (Linn.)

Authors: Vinod Yadav
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

Due to fewer side effects of herbal medicines, they have gained considerable importance in recent years. There is a booming business opportunity in herbal medicines market so it is important to tap the knowledge of our tribes in the area of herbal medicines. In the present paper, various medicinal properties such as antitussive, oxytoxic, insecticide, wound healing, and antispasmodic of Adhatoda vasica discussed. Based on these uses, it is concluded that this plant has a great potential to be used as drug in isolation as well as in combination with other drugs.

Keywords:
Toxicity analysis in concomitant chemoradiotherapy
versus accelerated radiation therapy following induction
chemotherapy in locally advanced head-and-neck
carcinoma in Indian scenario

Toxicity analysis in concomitant chemoradiotherapy versus accelerated radiation therapy following induction chemotherapy in locally advanced head-and-neck carcinoma in Indian scenario

Authors: K.P. Ranjan
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

Objective: Toxicity analysis in patients of locally advanced head and neck carcinoma (LAHNC) when induction chemotherapy (InCT) with TPF (docetaxel, carboplatin, 5-fluorouracil) is followed by concomitant chemoradiotherapy (CCRT) in one arm, and accelerated radiation therapy (RT) in other arm. Toxicity analysis in patients of locally advanced head-and-neck carcinoma (LAHNC) when induction chemotherapy (InCT) with TPF (docetaxel, carboplatin, and 5-fluorouracil) is followed by concomitant chemoradiotherapy (CCRT) in one arm and accelerated RT in other arm. Materials and Methods: Fifty patients with LAHNC were taken and divided into two arms of 25 each. All patients received three courses of 3-weekly InCT with docetaxel 80 mg/m2 , carboplatin 300 mg/m2 , and 5-fluorouracil 600 mg/m2 . This was followed by arm A patients receiving CCRT, wherein total radiation dose of 64 Gy/32 fractions/6.2 weeks (i.e., 2 Gy/fraction) with five fractions per week was given along with three weekly carboplatin 300 mg/m2 for three cycles. Arm B patients received accelerated RT given six fractions per week, total dose 64 Gy/32 fractions/5.2 weeks (i.e., 2 Gy/fraction). Results: Fifteen percentage of the total patients developed Grade 3 or 4 neutropenia during InCT. Grade 3 or 4 thrombocytopenia was seen 23% of all patients during InCT. Grade 3 or 4 neutropenia and thrombocytopenia was also reported in 31% and 23% patients of arm A during CCRT. Acute Grade 3 or 4 radiation dermatitis, mucositis, and pharyngitis was seen in 21%, 33%, and 12% patients of arm B as compared to 17%, 22%, and 9% patients of arm A, respectively, showing more of acute radiation reactions in the accelerated RT arm of the study. Late Grade 3 or 4 radiation-induced skin, mucosal, subcutaneous tissue, and salivary gland toxicity was not observed in any of the arms of the study. Disease status at last follow up, in arm A– 52% remained alive with no evidence of disease (NED), 39% remained alive with residual disease (RES) and 9% had locoregional recurrence (REC) while in arm B – 46% remained alive with NED, 46% remained alive with disease and 8% had locoregional recurrence. In arm B – 46% remained alive with NED, 46% remained alive with disease, and 8% had locoregional recurrence. Conclusion: InCT followed by either CCRT or accelerated RT are associated with slightly increased but manageable toxicity profile and good complete response rates. Therefore, both can be used as alternative treatment modality to CCRT alone in institutions where there is a lot of burden of patients and a long waiting list for RT.

Keywords: Accelerated radiation therapy, concomitant chemoradiotherapy, induction chemotherapy, locally advanced headand-neck carcinoma

About Europub

EuroPub is a comprehensive, multipurpose database covering scholarly literature, with indexed records from active, authoritative journals, and indexes articles from journals all over the world. The result is an exhaustive database that assists research in every field. Easy access to a vast database at one place, reduces searching and data reviewing time considerably and helps authors in preparing new articles to a great extent. EuroPub aims at increasing the visibility of open access scholarly journals, thereby promoting their increased usage and impact.