A study of diagnostic utility of serum ischemia modified albumin and IMA index in ischemic stroke and hemorrhagic stroke patients
Journal Title: Medpulse International Journal of Biochemistry - Year 2019, Vol 9, Issue 2
Abstract
Background: Stroke is associated with high morbidity and mortality rates, however, biochemical markers to aid in its early detection are lacking. As Ischemia Modified Albumin (IMA) is a novel marker for ischemia and previous studies have shown that its level increases acutely after ischemic stroke. Hence, it can be used to differentiate ischemic stroke from hemorrhagic and timely management of these patients. Objective: To compare levels of serum Ischemia Modified Albumin (IMA) in patients with ischemic and hemorrhagic stroke. Methods: Present cross sectional study comprised of 90 subjects, 30 ischemic stroke, 30 hemorrhagic stroke (definitive diagnosis based on radiological images) and 30 as apparently healthy control. Blood samples obtained within 24 hours of presentation were analysed for albumin by BCG dye binding method, IMA by albumin cobalt binding assay and albumin adjusted IMA index using formula by Lippi et al. Result: IMA concentrations were 0.340 ± 0.10 absorbance unit (ABSU) in control group, 0.45 ± 0.09ABSU in ischemic stroke and 0.38 ± 0.08ABSU in hemorrhagic stroke which were statistically higher (p< 0.0001) among stroke group as compared to control. There was also statistical significant difference (p< 0.003) of IMA concentrations between ischemic stroke and hemorrhagic stroke. A significant negative correlation between IMA and serum albumin (r = -0.75, p < 0.05) was observed. IMA index were 0.32±0.07 ABSU, 0.43±0.06 ABSU, 0.37±0.05 ABSU in control, ischemic and hemorrhagic stroke respectively and was highly significantly raised (p<0.0001) in ischemic stroke compared to hemorrhagic stroke and control. Conclusion: It is observed that IMA is a potential marker in diagnosing acute ischemia in cerebrovascular diseases as well as in differentiating types of stroke.
Authors and Affiliations
Sarika Argade, Reshakiran J Shendye
Keywords
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- EP ID EP521712
- DOI 10.26611/1002926
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