A STUDY ON EVALUATION OF EPIDURAL LEVOBUPIVACAINE 0.125% AND ROPIVACAINE 0.125% WITH AND WITHOUT FENTANYL FOR POSTOPERATIVE PAIN RELIEF IN ABDOMINAL SURGERIES
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 29
Abstract
BACKGROUND Postoperative pain forms an acute category of non-malignant pain. Uncontrolled postoperative pain may produce range of detrimental acute and chronic effects. Postoperative epidural analgesia is an effective and well accepted modality of pain relief techniques after abdominal surgeries. The present study is to compare post-operative analgesia with epidural infusion of ropivacaine 0.125%, ropivacaine 0.125% with fentanyl, levobupivacaine 0.125%, levobupivacaine 0.125% with fentanyl for 24 hours in abdominal surgeries. MATERIALS AND METHODS The present study consists of 120 patients who got admitted in Viswabharathi Hospital, Kurnool and underwent abdominal surgeries during October 2014 to October 2015. RESULTS In this clinical study, 120 healthy patients of either sex belonging to ASA grade-I and grade-II were included. The patients were divided into four groups, group A, group B, group C and group D. Group A- Thirty patients received 0.125% Ropivacaine infusion for 24 hours at rate of 8 ml per hour epidurally. Group B- Thirty patients received 0.125% Ropivacaine with fentanyl 1 microgram per ml at the rate of 8 ml per hour infusion for 24 hours epidurally. Group C- Thirty patients received 0.125% Levobupivacaine infusion at the rate of 8 ml per hour for 24 hours epidurally. Group D- Thirty patients received 0.125% Levobupivacaine with fentanyl 1 microgram per ml at the rate of 8 ml per hour for 24 hours epidurally. The study was to compare quality of analgesia, haemodynamic changes, side effects, any associated motor block, amount of local anaesthetic consumed among 0.125% ropivacaine, 0.125% with fentanyl, 0.125% levobupivacaine, 0.125% levobupivacaine with fentanyl when administered as continuous epidural infusion for 24 hours. Analgesia was superior in levobupivacaine with fentanyl infusion and least in plain ropivacaine infusion. Differences in analgesia found in levobupivacaine, ropivacaine with fentanyl and plain levobupivacaine was not clinically significant. CONCLUSION We conclude from present study that levobupivacaine with fentanyl is an attractive option for postoperative epidural analgesia. Ropivacaine with fentanyl and levobupivacaine with fentanyl were of equianalgesic efficacy. Studies with levobupivacaine for postoperative analgesia are limited unlike ropivacaine. From the present study, it was found that plain 0.125% ropivacaine infusion is of lower analgesic efficacy probably due to the shorter duration of action and less potency of ropivacaine.
Authors and Affiliations
Gunna Shantiraj, Sankula Kalyan
Keywords
Related Articles
- EP ID EP569193
- DOI 10.18410/jebmh/2018/450
- Views 56
- Downloads 0
RELATIONSHIP OF HEPATIC AND RENAL DYSFUNCTION WITH HAEMORRHEOLOGICAL PARAMETERS IN PLASMODIUM FALCIPARUM MALARIA
The clinical pattern of malaria has changed worldwide including India in last decade. Earlier cerebral malaria was the predominant manifestation of severe malaria, whereas now the combination of jaundice and renal failur...
LEFT VENTRICULAR DYSFUNCTION IN COPD WITH OR WITHOUT COR PULMONALE
BACKGROUND Chronic Obstructive Pulmonary Disease (COPD) is a disease state characterised by the presence of airflow obstruction due to chronic bronchitis or emphysema, which is progressive and partially reversible. Right...
PREDICTION OF OVARIAN RESPONSE BY ANTI-MULLERIAN HORMONE IN WOMEN WITH PCOS
BACKGROUND AMH would hinder the effect of FSH and participate in the pathogenesis of PCOS. This proof has led to hypothesise that there is a subgroup of women suffering from PCOS who have the excessive levels of AMH and...
EFFECT OF ADDING DEXMEDETOMIDINE VERSUS FENTANYL TO INTRATHECAL BUPIVACAINE ON SPINAL BLOCK CHARACTERISTICS IN GYNAECOLOGICAL PROCEDURESA COHORT STUDY
BACKGROUND Various adjuvants have been used along with local anaesthetics to prolong analgesia and to avoid intraoperative pain. Dexmedetomidine, a new highly selective α-2 agonist drug is now being used as a neuraxial a...
A STATISTICAL ANALYSIS OF LARYNGEAL MALIGNANCIES AT OUR INSTITUTION
BACKGROUND Malignancies of larynx are an increasing global burden with a distribution of approximately 2-5% of all malignancies with an incidence of 3.6/1,00,000 for men and 1.3/1,00,000 for women with a male-to-female r...