Comparative Studies on Conventional and Microwave Assisted Synthesis of Novel Quinoxalinone Derivatives as Antimicrobial Agents
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2016, Vol 4, Issue 1
Abstract
A facile green protocol has been developed for the synthesis of a series of 3-methylquinoxalin-2 (1H) -one substituted 1,2,4-triazole derivatives under microwave irradiation. Besides, these compounds were also synthesized by conventional heating procedures for comparison. In a relative study, microwave-assisted synthesis lead to higher yields of target compound within very short reaction time than conventional counterparts. The structures of these derivatives were ascertained through FTIR, Mass, NMR and elemental analysis. These target analogues were also found to exhibit considerable inhibitory activity against disease causing microorganisms.
Authors and Affiliations
Sweta Sahu, B. P Nagori, Vaibhav Dubey, Alok Semwal
Keywords
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