Creatinine estimation by compensated Jaffe method and enzymatic method - A comparative study
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 5, Issue 1
Abstract
Background: Chronic Kidney Disease is a global threat to health particularly for developing countries, since therapy is expensive and life-long. Incidence of CKD has doubled in the last 15 years. Accurate creatinine measurement is essential in the diagnosis of chronic kidney disease as serum creatinine is used for estimating glomerular filtration rate. The aim of our study was to compare the analytical performance between the enzymatic method and compensated Jaffe method for estimation of creatinine. Methods: In our study we measured serum creatinine in 135 serum samples by both enzymatic and compensated Jaffe methods using Cobas c311 automated analyser. Results: Relationship between both the methods using Cobas c311 automated analyser showed a correlation coefficient of 0.999, which means these two methods correlate very well. Conclusion: There was a good agreement and comparability between compensated Jaffe and enzymatic methods except for a minimal variation at higher concentrations of creatinine.
Authors and Affiliations
D Merriwin, P M Abraham Sam Rajan, N Ananthi
Keywords
Related Articles
- EP ID EP485945
- DOI 10.26611/1002519
- Views 170
- Downloads 0
Study of effects of Epigallocatectin-gallate (EGCG) on lipid profile and thereby cardiovascular risk
Background: Nowadays use of green tea has been increasing worldwide due to the beneficial effects it has on cardiovascular system. The beneficial effects of green tea can be attributed to the presence of various catectin...
Association of serum calcium level with metabolic syndrome: A case-control study
Background: Metabolic Syndrome (MetS) is highly prevalent in urban India. Circulating calcium has direct association with vascular disease like cardiovascular disease Calcium play crucial role in proper function of the i...
Uric acid and lipid ratios in lean normoglycemic patients of chronic kidney disease
Objectives: To investigate the derangement of lipid ratios in normoglycemic lean chronic kidney disease patients. To find out the correlation of uric acid with the lipid ratios. Materials and Methods: 50 lean (BMI <25) n...
Study of liver and kidney function tests in patients of hypothyroidism
Background: In India, thyroid disorders are most common among all endocrine Disorders and hypothyroidism being more common than hyperthyroid state and carcinoma thyroid. Thyroid hormones regulate the basal metabolic rate...
Assessment of thyroid dysfunction among diabetic patients attending to a rural teaching hospital
Aim: The present study aimed to find out the prevalence of thyroid dysfunction among diabetic patients in a rural teaching hospital. Materials and Methods: Two hundred twenty (220 cases) known diabetic patients who atten...