Development and validation of UV-Method for simultaneous estimation of Artesunate and Mefloquine hydrochloride in bulk and marketed formulation
Journal Title: Scholars Academic Journal of Pharmacy - Year 2013, Vol 2, Issue 4
Abstract
A simple, accurate, precise and economical Uv-method for estimation of Artesunate and Mefloquine HCL was developed. For analysis of Artesunate and Mefloquine HCl, 242nm and 256nm wavelengths were used respectively. The linearity range for Artesunate and Mefloquine HCl were 20-140µg/ml & 50-350µg/ml. Results of analysis were validated statistically, recovery studies for ART were 98.33-100.33 & for MEF 101.33-101.92. The LOD and LOQ were found to be 0.13μg/ml and 0.39μg/ml for ART. For MEF the LOD and LOQ values were found to be 1.53µg/ml & 2.21µg/ml the method was validated as per ICH guidelines. Keywords: Artesunate, Mefloquine HCL, UV-Spectroscopy.
Authors and Affiliations
Akshay D. Sapakal, Dr. K. A. Wadkar, Dr. S. K. Mohite, Dr. C. S. Magdum
Keywords
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