DIFFERENTIAL EFFECTS OF LOW AND HIGH MOLECULAR WEIGHT CHITOSAN ADMINISTERED INTRAPERITONEALLY TO MICE INFECTED WITH HELIGMOSOMOIDES POLYGYRUS
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2013, Vol 0, Issue
Abstract
Aim of the study was to compare the effect of different molecular weight chitosan on activity of peritoneal cells of mice during immunosupression caused by adult stages of Heligmosomoides polygyrus. We observed that intraperitoneal injections of chitosan induce cell infiltration, but the activity of recruited cells differed depending on the type of polysaccharide used. Low molecular weight chitosan activated cells with inflammatory characteristics, while high molecular weight polysaccharide reduced cell responsiveness to stimulation. Although IgA titers in the peritoneal fluid were elevated, chitosan treatments had no effect on the level of infection.
Authors and Affiliations
Klaudia Brodaczewska, Maria Doligalska
Keywords
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- EP ID EP73489
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