Effects of Ganoderma Lucidum on Palliative Cares In Oral Squamous Cell Carcinoma (Oscc) Patients: An Evidence of Excellent Postoperative Support for Cancer Patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 1
Abstract
Patients with oral squamous cell carcinoma (OSCC) respond to treatment modalities such as surgery and radiochemotherapy. Clinicians are, however, continuously testing other treatment combinations to see if they can improve the therapeutic results, lessen side effects or increase quality of life in cancer survivors. The aim of this study was to investigate the effectiveness of prescription of Ganoderma lucidum powder and/or extract on OSCC patients undergoing radiochemotherapy treatment following surgical removal of primary cancerous tissues. After surgery, G. lucidum was prescribed in three forms: G. lucidum powder capsule (500 mg/capsule), brushing teeth with dental paste (containing 0.5% extract) and drinking tea (containing 0.2% extract) thrice daily for three months. Then, the status of the OSCC patients was evaluated and compared against a placebo in terms of body weight gain, BMI, conditions of appetite, tolerability to radiotherapy, Karnofsky score and visual analog scale. Also, the levels of blood hemoglobin, urea, creatinine, total protein, albumin, and globulin, AST, ALT, ALP, TNF, LPO and P53 were measured to assess the effect of this mushroom. Body weight, BMI, and the levels of Hb, creatinine, urea, glucose, AST, ALT, ALP, total protein, albumin, globulin, TNF-α, p53 were also significantly ameliorated in the G. lucidum-prescribed patients, when compared to those of the placebo-prescribed OSCCpatients. The appearance of OSCC patients, appetite, Karnofsky score, visual analog scale and tolerability to radiochemotherapy were clinically improved. Our results, thus, support that G. lucidum, which has been used for antitumor effects since ancient times, has potential benefits in the palliative form of treatment for OSCC patients.
Authors and Affiliations
Masud Hossain, Sujan Bhowmick, Marzan Sarkar, Mafroz Ahmed Basunia, Bazlul Karim Choudhury, Shahdat Hossain
Keywords
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- EP ID EP578241
- DOI 10.9790/0853-1701108091.
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