Enhanced Dissolution Rate of Atorvastatin Calcium using Solid Dispersion with PEG 6000 by Dropping Method
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 8
Abstract
The solid dispersion was defined as the dispersion of one or more active ingredients in an inert carrier or matrix. The purpose of the study was to improve the physicochemical properties of Atorvastatin like solubility, dissolution properties and stability of poorly soluble drug by forming dispersion with Poly Ethylene Glycol (PEG) 6000 as water soluble carrier. Atorvastatin was formulated by physical mixtures and solid dispersions (dropping method) using 1:1, 1:2 and 1:3 ratios of drug and polymer (PEG-6000). The saturation solubility was carried using water and phosphate buffer solution (PBS) and showed marked increase in the saturation solubility than that of pure drug. Higher in vitro dissolution of solid dispersions was recorded compared to their corresponding physical mixtures and the pure drug. The dispersion with PEG-6000 (1:3) by dropping method showed faster dissolution rate (89.65%) as compared to other dispersions with PEG-6000 (1:1 and 1:2) whichever prepared by physical mixture and dropping method. The FT-IR shows the complexation and there were no interactions. Finally solid dispersion of Atorvastatin: PEG-6000 prepared as 1:3 ratio by dropping method showed excellent physicochemical characteristics and was found to be described by dissolution release kinetics and was selected as the best formulation in this study.
Authors and Affiliations
Lakshmi Narasaiah. V , Kalyan Reddy. B , Kishore. K , Raj Kumar. M , Srinivasa Rao. P , Venkateswara Reddy. B
Keywords
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