HEPATOPROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF Ocimum gratissimum LEAVES ON RIFAMPICIN-ISONIAZID INDUCED RATS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 5
Abstract
Ocimum gratissimum leaves used for treatment of jaundice in Ayurvedic medicine. Adult male wistar rats were rendered hepatotoxicity by Rifampicin-Isoniazid(50mg/kg each) by intraperitonially for 14days while leaf extract (100mg/kg and 200mg/kg) was administered orally for 14 days. Administration of leaf extract (100mg/kg and 200mg/kg) resulted in a significant (p<0.01) increased in plasma and hepatic lipid profiles. The extract suppresses cytochrome P-450 activity. Decreased levels of transaminases indicate stabilization of plasma membrane and protection of hepatocytes against damage caused by hepatotoxin. The levels of SOD, catalase, GSH significantly decreased along with concentration of malondialdehyde in these groups indicating increased lipid peroxidation. Histomorphological findings also supported the biochemical findings. The present study demonstrates that administration of leaf extract (100mg/kg and 200mg/kg) has significant hepatoprotective activity as evidenced by the biochemical, functional and histopathological parameters.
Authors and Affiliations
Sreenu Thalla,Venkata Ramana K, Delhiraj N
Keywords
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