Impact of PET-CT on Target Volume Delineation and Staging in Head and Neck Cancer
Journal Title: GUJARAT CANCER SOCIETY RESEARCH JOURNAL - Year 2017, Vol 19, Issue 2
Abstract
Contrast Enhanced Computed Tomography is the imaging of choice in head and neck malignancies. This study is undertaken to evaluate the impact of Hybrid PET-CT scan on target volume delineation and staging and compare it to CT alone volumes in head and neck cancers. A total of 25 patients of squamous cell carcinoma of oropharynx (n = 20) and hypopharynx (n = 5) were included.FDG-PET and CECT scan were performed in a single session as a part of radiotherapy treatment planning for Intensity modulated radiotherapy. Hybrid PET/CT imaging led to a change in 7 out of 25 patients, i.e. 28% as compared to CT alone in our study.The mean primary GTV volumes on PET-CT and CT were significantly different ( PETCT_ GTV : 32.42 ± 15.92 cc vs. CT_GTV : 28.52 ± 15.08 ). The difference between the two target volumes was statistically significant ( p =0.004). Recurrence patterns following IMRT show that most of them are in the high-dose region. Thus, PET-CT has the advantage of functional imaging apart from anatomical detailing. These biological target volumes (gross tumor volume delineated on PET) canbe included in the radiotherapy planning in head and neck cancers and could potentially be used for higher boost to the primary site.
Authors and Affiliations
Mridul Anand, Jigna Bhattacharya, Rekesh Vyas, Sumit Goyal, U Suryanarayan, Swati Rachh, Omprakash Sinha
Keywords
Related Articles
- EP ID EP334073
- DOI -
- Views 48
- Downloads 0
Randomized Study of Oral Misoprostol for Cervical Ripening before Intracavitary Brachytherapy for Carcinoma Uterine Cervix
Intracavitary brachytherapy forms an integral part of treatment of carcinoma cervix and the complications arising out of the procedure are partly related to the difficulties in cervical dilatation. This study aims to eva...
Nasopharyngeal Carcinoma in Pediatric Population: A Retrospective Analysis
Nasopharyngeal carcinoma in pediatric patients is a rare malignancy. Majority of the patients present with locally advanced disease for which neoadjuvant chemotherapy followed by chemoradiation is the preferred regimen....
FLT3 Protein Expression and Mutation in B Cell Acute Lymphoblastic Leukemia (B-ALL)
FLT3 is a receptor tyrosine kinase, which play important role in normal hematopoiesis activating mutations of FLT3 are commonly found in acute leukemia patients and reported to be associated with poor clinical outcome. T...
About the Journal and Instructions to Author
About the Journal and Instructions to Author
Isolated Central Nervous System Blast Crises in Chronic Myelogenous Leukemia
Chronic myeloid leukemia (CML) is a chronic myeloproliferative disorder, currently treated with tyrosine kinase inhibitors. Uncontrolled CML eventually progresses to accelerated and blast crises, which is often medullary...