Linagliptin inhibits the growth of human glioblastoma cells
Journal Title: International Neuroscience Conference (NEURO-2023) - Year 2023, Vol 4, Issue 1
Abstract
Glioblastoma is among the most aggressive brain tumors. The prominent features of this tumor include aberrant cell proliferation, a high probability of recurrence, immunosuppression, severe angiogenesis, and infiltrative behavior. Proteases of the cell surface or extracellular matrix (ECM) can contribute to these features by mediating the breakdown of ECM components, regulating the activity of paracrine agents, liberating growth factors of ECM, and shedding cell surface proteins. The dipeptidyl peptidase-4 (DPP-4), a multifunctional membrane-bound protease, is associated with the development and progression of several cancers including glioma. High expression of DPP-4 predicts poor prognosis in glioma patients. Nevertheless, the effects of DPP-4 inhibitors on glioblastoma remain largely unknown. In the present study, we evaluated the effects of linagliptin (a DPP-4 inhibitor) on U87 human glioblastoma cells and compared its effects with temozolomide. It could reduce the survival, proliferation, and migration ability of the glioblastoma cells and increase the intracellular level of reactive oxygen species in a time- and concentration-dependent manner. If clinical trials confirm the results of our study, DPP-4 inhibitors such as linagliptin can be used as add-on therapy with other medications (temozolomide) against brain tumors.
Authors and Affiliations
Ahmad Ghorbani, Roghayeh Rashidi, Shahrzad Anghozeh Yazdi
Keywords
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