Nanotechnolgy a Novel Ocular Drug Delivery: A Review
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2017, Vol 5, Issue 1
Abstract
Ocular drug delivery is one of the challenging tasks due to the unique structure of eye which restricts the entry of drug at the site of action. The protective mechanisms of the eye decrease the bioavailability of drug. Conventional ocular dosage form including eye drops are no longer sufficient to ocular diseases. There are most commonly available ophthalmic preparations such as drops and ointments when instilled into eye they are rapidly drained away from the ocular surface. So to overcome these problems newer pharmaceutical formulation such as nanoparticle, liposome, nanosuspension, microemulsion, iontophoresis have been developed to increase the bioavailability Utilization of nanotechnology presents new avenue of drug system development with potential to penetrate protective barriers and sustain ample tissue saturation. This review provides barriers of ocular drug delivery, summarizes recent findings and advantages of various nanocarriers systems like nanosuspensions, nanoparticles, nanocrystal in the field of ocular drug delivery and review also summarizes the various method of preparation for nanotechnology based ocular delivery.
Authors and Affiliations
Rainu Devi, Charanjeet Kaur, Vaishali Goel, Aman Kumar, Ujjwal Nautiyal
Keywords
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