FORMULATION AND EVALUATION OF ENTERIC COATING TABLETS BY WET GRANULATION METHOD
Journal Title: Int J of Pharm Res & Analy - Year 2014, Vol 4, Issue 3
Abstract
Serratiopeptidase is derived from bacteria belonging to genus Serratia. Serratiopeptidase tablets used in the treatment of viral diseases and hepatitis. Serratiopeptidase were formulated using HPMC phthalate as enteric coating polymer in different concentrations to optimize delayed drug release profile and to target the drug release in the small intestine regions. The present work was made to develop enteric coated tablets containing Serratiopeptidase tablets were made by direct compression method. The tablets were evaluated for physical characterization, in vitro release study and stability studies. Results of in vitro release profile indicated that formulation F1 was the most promising formulation as the extent of drug release from this formulation was optimum and match with the In-house Specification when compared to other formulations.
Authors and Affiliations
B. Shibu , S. Suresh , M. Purushothaman , C. Saravanan2 , C. J. Lissy Joice
Keywords
Related Articles
- EP ID EP157996
- DOI -
- Views 129
- Downloads 0
[b]TRACKING BIOACTIVE CONTENT IN BUTANOL EXTRACT OF CITRULLUS COLOCYNTHISL. FRUIT PULP BY GC/MS [/b]
Citrullus colocynthis (L.) a member of Cucurbitaceae family, was collected from the different areas of the Kachchh region. The fruit pulp of Citrullus colocynthis (L.) was subjected to continuous and successive sox...
ANALYTICAL METHOD DEVELOPMENT & VALIDATION FOR SIMULTANEOUS ESTIMATION OF PANTOPRAZOLE AND MOSAPRIDE IN PHARMACEUTICAL DOSAGE FORM BY RP-HPLC METHOD
A simple, specific and accurate reverse phase high performance liquid chromatographic method was developed for the simultaneous determination mosapride and pantoprazole in pharmaceutical dosage form. The column used was...
DEVELOPMENT AND VALIDATION OF NEW SPECTROPHOTOMETRIC METHODS FOR THE QUANTITATIVE ESTIMATION OF SILODOSIN IN BULK DRUG AND PHARMACEUTICAL FORMULATIONS
Three simple, sensitive, accurate and rapid spectrophotometric methods A, B and C have been developed for the quantitative estimation of Silodosin in bulk drug and also pharmaceutical formulations. Method A is a UV...
A REVIEW ON CURRENT TRENDS AND ADVANCEMENTS IN BIOANALYTICAL METHODS
This paper reviews the recent developments in bio-analysis sample preparation techniques and chromatographic techniques give an update on basic principles and a comparative discussion on the benefits and limitation of ev...
DEVELOPMENT OF UV SPECTROSCOPIC METHOD FOR THE DETERMINATION OF GUAIFENESIN IN BULK AND FORMULATION
The present research work discusses the development of UV Spectroscopic method for the estimation of Guaifenesin. Simple, specific, accurate and cost effective spectroscopic method has been developed for the estimation o...