Ni and Al mixture amplifies cerebellar oxido-inflammatory responses, down regulates AchE activity and BDNF/NGF levels in motor impairment in male albino rats.
Journal Title: International Neuroscience Conference (NEURO-2023) - Year 2023, Vol 4, Issue 1
Abstract
Aluminum and nickel are potent neurotoxicants to which humans are constantly exposed. Previous studies have demonstrated that these two metals can affect the motor system, but their effects on the cerebellum, a central nervous system region with the highest number of neurons (over 45 billion), have remained largely unexplored. Therefore, we conducted a study to investigate the adverse effects of Al, Ni, and Al+Ni in vivo. In our study, seven male Sprague Dawley rats per group were orally exposed to distillate water, 0.2 mg/kg of Ni, 1mg/kg of Al, and 0.2 mg/kg of Ni + 1mg/kg of Al (as a binary heavy metals mixture; HMM), respectively. Ni, Al, and HMM exposed rats accumulated higher levels of Al and Ni compared to controls, and HMM treated animals had higher levels of Ca and Fe in the cerebellum (p<0.05). Malondialdehyde (MDA) levels were significantly (p>0.05) higher in the HMM, Ni, and Al treated groups compared to the control group that received deionized water. Superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GPx) activities were significantly (p>0.05) reduced in the HMM, Ni, and Al treated groups compared to the control group that received deionized water. We also found that the nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels were significantly decreased in the nickel, aluminum, and heavy metal mixture groups compared with the control group. Moreover, there was a significant increase in the activity of acetylcholinesterase (AchE) and a decrease in cyclooxygenase-2 (COX-2) activity in the nickel, aluminum, and HMM treated groups compared to the control group. HMM exposed animals had significantly worse results in the Rotarod test (p<0.05) than controls. Aluminum and nickel induced impairment of cerebellar function at various levels.
Authors and Affiliations
Chidinma P Anyachor, Anthonet N. Ezejiofor, Orish E. Orisakwe*, Chinna N. Orish
Keywords
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