Number and distribution of mast cells in lesions of large intestine
Journal Title: Medpulse International Journal of Pathology - Year 2018, Vol 5, Issue 3
Abstract
Background: Mast Cells are bone marrow derived and express a variety of phenotypic features within tissues as determined by the local environment. In the gastrointestinal tract mast cells are part of the allergic response to luminal antigens and of protective innate immune responses. The gastrointestinal tract is a rich source of mast cells. The active metabolic products of the mast cell influence gastrointestinal secretion, absorption, and motility through paracrine effects of local mast cell activation and cause systemic effects through the release of cellular products into the blood stream. Aims and Objectives: Study was undertaken to study the number and distribution of mast cells in lesions of large intestine. Material and Methods: Sections from received large intestine specimens were taken from normal resection margin, lesion and adjacent to lesion. HandE and 1% Toludine blue staining were done. The average number of mast cell counted in 10 non-overlapping high power field of mucosa and submucosa was obtained. Result and Conclusion: In all cases (neoplastic and non-neoplastic) lesions of large intestine, number of mast cells is more in submucosa compared to mucosa. Also, noted that the highest number of mast cell are seen in normal resection margin as compared adjacent to the lesion, and lesion site.
Authors and Affiliations
Neha Sood, Shachi 1, Rashmi Gautam, Anil Kumar
Keywords
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