Predictive Value of Biomarkers for Normal and Pathological Ageing in a Rat Model
Journal Title: International Journal of Food Science, Nutrition and Dietetics (IJFS) - Year 2015, Vol 0, Issue 6
Abstract
Sub-optimal diets are widely known to be associated with disease. This study investigated two questions: first, whether a Western affluent diet affects long-term health in the rat, and second, whether, and to what extent, early changes in blood biomarkers can predict specific pathologies. A rat model was used in which animals were fed from weaning either a control diet or a high fat, low protein, energy dense Western affluent diet. Rats were harvested at either 12 or 18 months, and at these time points blood samples were taken and various clinical biomarkers measured using a hospital analyser or by ELISA. Predictive biomarkers should show small changes at early time points and larger changes at later time-points, and be associated with disease(s). Tissues were examined for overt pathology, and data were mined to establish links between pathologies and specific blood markers that might be used predictively. Results showed that the Western affluent diet is associated with ill-health, with a relative risk of developing disease 4.5 times higher than for the control diet. Furthermore we conclude that triacylglycerol, HDL cholesterol, the ratio of total cholesterol to HDL cholesterol, creatinine and alanine aminotransferase were good predictors of disease as across the cohorts they showed altered levels before the clinical development of pathologies, in agreement with our hypothesis.
Authors and Affiliations
H. Mac Queen
Keywords
Related Articles
- EP ID EP201938
- DOI 10.19070/2326-3350-SI03003
- Views 115
- Downloads 0
Adequacy of Medical and Surgical Residents' Nutritional Education
Background and Objectives: Over the past years, nutritional and life style modifications have become an important adjunct to medical therapy especially with the widespread obesity epidemic. Furthermore, diseases related...
Development and Evolution of Antioxidant Rich Fruit Beverage
The purpose of this study was to developed and analyzes Antioxidant rich fruit beverages to determine antioxidant concentrations. It may provide protection differently against oxidative stress because they are different...
Assessment of Knowledge, Attitude and Practice Towards Whole Grains Among Children Aged 10 and 11 Years In Kuala Lumpur, Malaysia
Introduction: The potential contribution of knowledge, attitude and practices (KAP) studies towards whole grains on childhood obesity research and control has not received much attention in Malaysia. This study aimed to...
Physiological Effect of Chromium Exposure: A Review
Human exposure to metals is common due to their wide use in industry, and environmental persistence. The heaviest metal exposures occurred in the workplace or in environmental settings in close proximity to industrial so...
Inhibitory Effects of oxalic acid on Listeria monocytogenes, Salmonella Enteritidis and Escherichia coli O157:H7 inoculated onto Chicken Breast stored at 4°C
Oxalic acid was evaluated for its effectiveness in inhibiting growth of selected pathogens on raw chicken breasts. Inoculated chicken breasts were dipped in oxalic acid solutions (0, 0.5, 1.0, 1.5 and 2.0% w/v) for 10, 2...