Risk factors of hypoxaemia in patients with end-stage liver cirrhosis

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Risk factors of hypoxaemia in patients with end-stage liver cirrhosis

Journal Title: Di-er Junyi Daxue Xuebao - Year 2008, Vol 29, Issue 12

Abstract

Objective:To screen for risk factors for hypoxaemia and heptopulmonary syndrome (HPS) in patients with end-stage liver diseases by analyzing the preoperative incidence of HPS,so as to provide evidence for anaesthesia management during the perioperative peroid.Methods: The clinical data of 214 patients with liver cirrhosis,who received liver transplantation from May 2001 to Sep. 2005 in Changzheng Hospital,were retrospectively investigated.The statistical package of SAS 6.12 was used to analyze the state of oxygenation.The standard of hypoxaemia and HPS was AaPO2>20 mmHg(1 mmHg=0.133 kPa)and PaO2<70 mmHg.The correlation of PaO2 with duration of mechanical ventilation and intensive care unit (ICU) stay was analyzed.Results: It was showed that the 214 patients often suffered from hypoxaemia.PaO2 was found correlated with Child-Pugh classification,hydrothorax,total bilirubin,ammonia,and lactic acid,with the values of r being -0.22,-0.16,-0.17,0.20,and -0.29,respectively.PaCO2 was correlated with haemoglobin and serum albumin,with the values of r being 0.23 and 0.13,repectively.AaPO2was not correlated with spider naevi,liver palms or Child-Pugh class; PaO2 was not correlated with spider naevi or liver palms.PaO2 was negatively correlated with the duration of mechanical ventilation and ICU stay (r=-0.388 81,P=0.000 1;r=-0.176 84,P=0.010 4).Conclusion: Patients with liver cirrhosis often suffer from hypoxaemia; the incidence of hypoxaemia is correlated with preoperative liver function classification and other related factors,and has great influence on duration of technical ventilation and ICU stay.The incidence of hypoxaemia and HPS should be evaluated before liver transplantation in patients with end-stage liver cirrhosis,so as to benefit perioperative management.

Authors and Affiliations

Li Ma

Keywords

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EP ID EP82957
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