Sleep and Brain Maturation in Typically Developing and Drug-Naïve ADHD Children
Journal Title: The 1st Annual Meeting of Georgian Center for Neuroscience Research - Year 2020, Vol 2, Issue 20
Abstract
Adolescence is a dynamic transition period from childhood to adult life that is characterized by a fundamental neurobiological reorganization for both the brain and the body. Neuroscientists have made great advances in identifying the cognitive and behavioral correlates of such reorganization. Sleep is one aspect of behavior that changes greatly across adolescence. Developmental research provide the evidence that sleep EEG undergoes fundamental changes across adolescence and these changes represent one of the component of a widespread brain maturation process. Adolescence is a highly sensitive period for the emergence of many psychiatric disorders, largely due to variations in brain maturation processes. Sleep EEG recordings, as a possibility to detect aberrations from developmental trajectories that normally occur in the adolescent brain, has a potential to provide insights into a number of neurodevelopmental health problems that emerge during this critical period of development. Current evidence of sleep behavior and sleep EEG changes across adolescence indicate that maturational sleep EEG changes are particularly prominent in non-rapid eye movement (NREM) sleep. The decline in NREM sleep delta and theta activity across adolescence reflect maturational changes driven by cortical synaptic pruning. ADHD is the most commonly diagnosed neurodevelopmental disorder occurring in about 5 % of children, and the most common behavioral concern in pediatric settings. The growing evidence from neuroimaging studies indicate that ADHD is a problem of delayed rather than deviance in cortical maturation. Brain electrophysiological evidence for a maturational delay is mixed. The adolescent decline in sleep slow wave EEG activity provides an opportunity to investigate this question by looking at NREM sleep delta and theta maturation. Data concerning developmental changes in sleep EEG across adolescence in typically developing and drug-naïve ADHD children will be presented.
Authors and Affiliations
Nato Darchia
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- EP ID EP677965
- DOI 10.29088/GCNR-2020.56
- Views 176
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