Study of effect of solubility of a sparingly water soluble drug in presence of surfactant
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 5
Abstract
Solubility plays an important role in dissolution and absorption of drug. Benzoic acid has less solubility in aqueous media. The aim of present study was to study the effect of solubility enhancing agents at room temperature on the solubility of benzoic acid. Sodium Lauryl Sulphate (SLS) in various concentrations were used to study the solubility of Benzoic acid in water. The solubility of benzoic acid in water is directly proportional to the concentration of the surfactant added. The solubility of benzoic acid increases with increase in concentration of surfactant.
Authors and Affiliations
Ashish Kumar Gupta*| Department of pharmacy, V.B.S.Purvanchal University, Jaunpur, Amita Tilak| Department of pharmacy, G.S.V.M. Medical College, Kanpur, Sudhir Singh Gangwar| Department of pharmacy, G.S.V.M. Medical College, Kanpur, Minakshi Verma| Department of pharmacy, G.S.V.M. Medical College, Kanpur
Keywords
Related Articles
- EP ID EP3746
- DOI -
- Views 361
- Downloads 18
POSTMENOPAUSAL OSTEOPOROSIS IN OBESE WOMEN
Obesity and osteoporosis are two common diseases with an increasing prevalence and a high impact on morbidity and mortality. Obese women have always been considered protected against osteoporosis. Fat and bone are linked...
OCCURRENCE OF MALIGNANT TUMORS OF PARANASAL SINUSES IN KARNATAKA
Introduction: malignancy of paranasal sinuses is wide spread. Paranasal sinuses are in close anatomical relationship with skull viscera. Clinical assessment get hampered by surrounding bony structures, diagnostic radiolo...
Microbiological profile and antibiotic susceptibility pattern of uropathogens in Anand district of Gujarat, India.
Background: Antimirobial drug resistance in urinary tract pathogens is a challenging problem to the medical practitioners & important reason for increased morbidity and healthcare expenditure. Aim/Objective: To document...
MESSENGER RNA–FABRICATED VACCINES FOR TUMOR
Messenger RNAs are non-lethal molecules which state the deficiencies of recombinant virus or DNA-based immunization treatments. The physiological part of mRNA is to exchange hereditary informative data from the nucleus...
PERINATAL OUTCOMES ASSOCIATED WITH MECONIUM STAINED NON VIGOROIUS BABIES IN A TERTIARY CENTRE OF UTTARAKHAND (INDIA)
We examined the perinatal outcomes in singleton pregnancies associated with meconium-stained amniotic fluid (MSAF) in non vigorous neonates.The study was performed during one year (2012-2013) in new borns admitted at o...