Synthesis, characterization and Biological activity of Copper (II), Cobalt (II), Nickel (II) and Mercury (II) complexes of Schiff base derived from 2-Acetyl-5-chloro thiophene-o- Phenylenediamine
Journal Title: International Journal of Pharma Research and Health Sciences - Year 2014, Vol 2, Issue 5
Abstract
The Metal complexes of Co (II), Ni (II), Cu (II) and Hg (II) with a new Schiff base derivedfrom 2-Acetyl 5-chloro thiophene and o-Phenylenediamine in methanol are reported. The complexeshave been characterized using chemical analysis, (IR, UV-VIS, H1-NMR),conductometric and magnetic data. According to these data, we propose an octahedral geometry formetal (II) complexes. The invitro antibacterial activities of the investigated complexes were evaluatedagainst few microorganisms by well diffusion technique. It was found that the metal complexes havehigher activity that the standard drugs. Antibacterial activity of the ligand and its complexes werestudied against to gram positive bacteria; Staphylococcus aureusandBacillus subtilisandgramnegative bacteria Salmonella typhiandE. coli
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