THE BENEFICIAL EFFECT OF ETHANOLIC EXTRACT OF MORINGA OLEIFERA ON OSTEOPOROSIS
Journal Title: International Journal of Pharmaceutical Applications - Year 2010, Vol 1, Issue 1
Abstract
Several animal and clinical studies have shown that phytoestrogens, plant derived estrogenic compounds can be useful in treating post menopausal osteoporosis. Phytoestrogens and phytoestrogen containing plants are currently under active investigation for their role in estrogen related disorders. The present study deals with anti-osteoporotic evaluation of phytosterol rich plant Moringa oleifera, commonly known as Drumstick. 3 Month old female wistar rats were bilaterally ovariectomised (OVX) and randomly assigned to 3 groups (6 rats/group). Additional 6 animals were sham operated. OVX and sham control groups were orally administered with vehicle while the other two OVX groups were administered 0.15 mg/kg estradiol and 1 g/kg of ethanolic extract of Moringa oleifera leaves in two divided doses for 6 weeks. At the end of the study blood, bones of the animals were collected. Serum was evaluated for Calcium, phosphorus, alkaline phosphatase. Results were analyzed using ANOVA. Ethanolic extract of Moringa oleifera (6oomg/kg, p.o.) significantly reduced urinary calcium excretion and significantly increased calcium content of bones in comparison to OVX control. Unlike estradiol it did not affect body weight gain in OVX animals. Ethanolic extract of Moringa oleifera prevented Ovariectomy induced bone loss in rats. The osteoprotective effect was comparable with estradiol.
Authors and Affiliations
Sanganna C. Burali , Vishnu kangralkar , Om sai sravani , S. L. Patil
Keywords
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