THE INFLUENCE OF POLYMORPHISM ASP299GLY OF TLR4 GENE AND GLN11LEU OF TLR7 GENE ON THE EFFICIENCY OF ANTIVIRAL THERAPY OF CHRONIC HEPATITIS C
Journal Title: Гепатологія - Year 2016, Vol 32, Issue 2
Abstract
Th e aim of the study was to analyze the infl uence of polymorphism Asp299Gly of TLR4 gene and Gln11Leu of TLR7 gene on the eff ectiveness of antiviral therapy (AVT) of chronic hepatitis C (CHC) with pegylated interferon (PEG-IFN) and rib- avirin (RBV). To achieve this goal we conducted a prospective cohort study of 125 patients with CHC. Th e study found: that the presence of polymorphism Asp299G- ly of TLR4 gene in patients with HCV aff ects the effi ciency of the AVT PEG-IFN- RBV: а frequency to achieve an early virological response is reduced in 1.3 (p=0.018; rS= –0.237, p=0.008), direct – in 1.5 (p=0.020; rS=–0.259, p=0.008), sustained – in 1.5 (р=0,020; r= –0.226, р=0.015) times. No identifi ed а statistically signifi cant diff erence between the effi ciency of the AVT PEG-IFN-RBV in CHC with «wild» Gln11Gln and «mutant» Gln11Leu+Leu11Leu genotypes of TLR7 gene.
Authors and Affiliations
G Dubinskaya, L Sizovа, T Koval, E Izyumskaya
Keywords
Related Articles
- EP ID EP250367
- DOI -
- Views 114
- Downloads 0
CORRELATION OF CLINICAL AND LABORATORY PARAMETERS IN PATIENTS WITH BENIGN HYPERBILIRUBINEMIA
For analysis of the clinical picture and the establishment of benign functional hyperbilirubinemia markers 63 men, 29.08 ± 1.65 years old, who were undergoing in- patient treatment at hospital, were examined....
STATINS AND HEPA-MERZ IN THE TREATMENT OF PATIENTS WITH ISCHEMIC HEART DISEASE
Th e results of the study of the functional condition of the liver and lipid profi le in patients with unstable angina infl uenced by the treatment with rosuvastatin and Hepa-Merz have been presented in the article. It...
PECULIARITIES OF INNATE IMMUNITY REACTION TO HBV INFECTION
Modern data from Ukranian and foreign literature resources concerning inborn immunity during HBV infection have been presented in the review. It is known that immunological mechanisms which cause self-limitation or dev...
FIRST MECHNYKIVSKI READINGS
Review of scientific practical conference with participation of international specialists “Mechnykivski readings – 2016”. Urgent problems of parenteral infections”. Kharkiv, 12-13 May 2016.
MINERAL HOMEOSTASIS IN FUNCTIONAL DISORDERS OF THE LIVER IN SOLDIERS OF ANTITERRORIST OPERATION WITH BRAIN INJURY OF MILD AND MODERATE SEVERITY
Th e article is dedicated to the study of interconnection of brain metabolism impairment in craniocerebral injury of mild and moderate severity in soldiers of antiterrorist operation with changes...