The role of survivin in the diagnosis and therapy of gynaecological cancers

Journal Title: Advances in Hygiene and Experimental Medicine - Year 2016, Vol 70, Issue

Abstract

Survivin is a member of the family of apoptosis inhibitors. It regulates several essential cellular processes, i.e. it inhibits apoptosis and promotes cell proliferation, DNA repair and autophagy. Survivin is responsible for development of the cell’s resistance to chemotherapy and radiotherapy. Overexpression of survivin generally correlates with poor prognosis. Its presence has been detected in most types of human tumours. Currently much attention is paid to the possibilities of using this protein as a diagnostic marker of cancer or a prognostic factor. Survivin occurs selectively in cancer cells and is essential for their survival. These features make survivin a promising target for cancer therapy. There are some strategies for discovering survivin inhibitors. The most common strategies are antisense nucleotides, RNA interference and small molecule inhibitors of protein. Scientists are also working on using survivin to induce an immune response in cancer patients. This article discusses the potential role of survivin in the diagnosis of various types of cancer, as well as selected strategies for the inhibition of both gene expression and protein function. Detailed knowledge of the mechanisms of survivin action may therefore be crucial for effective antitumor therapy development.

Authors and Affiliations

Marta Denel-Bobrowska, Agnieszka Marczak

Keywords

Related Articles

BNIP3 as an atypical representative of the Bcl-2 protein family. Part 1: BNIP3, a regulator of non-apoptotic programmed cell death

BNIP3 is classified as a member of the Bcl-2 protein family that regulates programmed cell death and of the BH3-only protein subfamily as it only contains one BH domain. However, the transmembrane domain of BNIP3 is invo...

The effects of endocrine disrupting chemicals on the human organism

The development of civilization has not only improved the quality of life, but it is also responsible for increasing environmental pollution. Between 80000-100000 previously unknown chemicals have been estimated to circu...

Immunoregulation by interference RNA (iRNA) – mechanisms, role, perspective

The functioning of an organism depends on the precise control mechanisms, constantly adjusted to the actual state. Therefore, there is a need for efficient communication between both adjacent and distant cells, which ma...

Clinical usefulness of serum free light chains measurement in patients with multiple myeloma: comparative analysis of two different tests

Introduction: There are two commercially available tests for measurement of serum free light chains (sFLC) in multiple myeloma (MM) patients – Freelite and N Latex FLC. The aim of this study was to perform an assessment...

Insulinooporność a przewlekła reakcja zapalna

Insulinooporność jest stanem zmniejszonej odpowiedzi biologicznej tkanek na insulinę. Badania ostatnich lat spowodowały wzrost zainteresowania rolą przewlekłej reakcji zapalnej o niskiej aktywności w patogenezie insulino...

Download PDF file
  • EP ID EP206091
  • DOI -
  • Views 166
  • Downloads 0

How To Cite

Marta Denel-Bobrowska, Agnieszka Marczak (2016). The role of survivin in the diagnosis and therapy of gynaecological cancers. Advances in Hygiene and Experimental Medicine, 70(), 1182-1189. https://europub.co.uk/articles/-A-206091