The role of survivin in the diagnosis and therapy of gynaecological cancers

Apply

The role of survivin in the diagnosis and therapy of gynaecological cancers

Journal Title: Advances in Hygiene and Experimental Medicine - Year 2016, Vol 70, Issue

Abstract

Survivin is a member of the family of apoptosis inhibitors. It regulates several essential cellular processes, i.e. it inhibits apoptosis and promotes cell proliferation, DNA repair and autophagy. Survivin is responsible for development of the cell’s resistance to chemotherapy and radiotherapy. Overexpression of survivin generally correlates with poor prognosis. Its presence has been detected in most types of human tumours. Currently much attention is paid to the possibilities of using this protein as a diagnostic marker of cancer or a prognostic factor. Survivin occurs selectively in cancer cells and is essential for their survival. These features make survivin a promising target for cancer therapy. There are some strategies for discovering survivin inhibitors. The most common strategies are antisense nucleotides, RNA interference and small molecule inhibitors of protein. Scientists are also working on using survivin to induce an immune response in cancer patients. This article discusses the potential role of survivin in the diagnosis of various types of cancer, as well as selected strategies for the inhibition of both gene expression and protein function. Detailed knowledge of the mechanisms of survivin action may therefore be crucial for effective antitumor therapy development.

Authors and Affiliations

Marta Denel-Bobrowska, Agnieszka Marczak

Keywords

apoptoza cykl komórkowy immunoterapia kaspazy surwiwina Apoptosis Caspases Cell Cycle

Retinol-binding protein 4 (RBP4) as the causative factor and marker of vascular injury related to insulin resistance

One of adipokines involved in the development of insulin resistance is retinol-binding protein 4(RBP4). The physiological role of RBP4 is transport of retinol from the liver to peripheral tissues. One of the first events...

Choroba Alzheimera a produkty degradacji białka APP. Formowanie i różnorodność form fibrylujących peptydów – wybrane aspekty

Peptydowe produkty degradacji białka APP (Amyloid Precursor Protein, APP), to najważniejsze białka w patofizjologii choroby Alzheimera (Alzheimer’s disease, AD). Choć dobrze już poznane, jednak nadal budzą zainteresowani...

EP ID EP206091
DOI -
Views 167
Downloads 0