The role of TGF-β-related signal transduction pathways in pathogenesis of epithelial-mesenchymal transition as a key element in cancer development and progression
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2012, Vol 66, Issue 0
Abstract
Epithelial-mesenchymal transition (EMT) is a biological process that drives polarized, immotile epithelial cells to undergo multiple biochemical changes to acquire a mesenchymal cell phenotype. The characteristic features of EMT are cell apolarity, loss of cellular adhesion, reduced expression of E-cadherin and increased migratory capacity, as well as invasiveness. EMT is a physiological process that is essential for normal embryonic development. Additionally, abnormal activation of EMT contributes to some human pathologies such as tissue fibrosis, cancer cell invasion and metastasis. In both situations, the basic molecular mechanisms are similar, but lead to different effects depending on cell type and biological conditions of the environment. TGF-β is a multifunctional cytokine that controls proliferation, differentiation and other functions in many cell types. It has been found that neoplastic development converts TGF-β into an oncogenic cytokine. It activates various molecular processes, which are engaged in EMT initiation. All that makes TGF-β a key regulator of EMT.
Authors and Affiliations
Małgorzata Pieniążek, Piotr Donizy, Marcin Ziętek, Bartłomiej Szynglarewicz, Rafał Matkowski
Keywords
Related Articles
- EP ID EP66756
- DOI -
- Views 157
- Downloads 0
Investigation of antiradical potential of different kinds of teas and extracts from these teas using antiradical activity units (TAU)
Introduction: Green, black and pu-erh teas are known to have strong antiradical properties in comparison to other plant raw materials. In this study fifteen different teas belonging to three types, green, black, and pu-...
Toll-like receptors in viral hepatitis
Toll-like receptors (TLRs) are part of the innate immune system. They recognize some protein, lipid, and nucleic structures that are common in microorganisms such as bacteria and viruses but not present in the human body...
Heterogenność ludzkiego genu WT1
Gen WT1, charakteryzujący się niezwykle złożoną strukturą, jest umiejscowiony w obrębie chromosomu 11. Bierze udział w regulacji wzrostu i rozwoju komórek, ma także znaczny wpływ na etapy funkcjonowania organizmu. Gen WT...
The influence of cotinine on the non-small-cell lung cancer line A549
The aim of this investigation was to determine the influence of cotinine on the non-small-cell lung cancer line A549. The material for the study was the A549 cell line. The cells were subjected to 24-h incubation with co...
Resistance of Pseudomonas aeruginosa to antibiotics
The main problem in the treatment of nosocomial infections is the increasing drug resistance of microorganisms that cause them, limiting the number of effective antibiotics. Pseudomonas aeruginosa bacilli are the cause o...