Tranexamic acid in intensive therapy of bleeding with different genesis
Journal Title: Серце і судини - Year 2019, Vol 0, Issue 3
Abstract
The problem of acute bleeding is relevant both in the medical and in the organizational aspects, and not only for Ukraine. The success of treatment is determined by a timely diagnosis and the speed of emergency medical care. Emergency surgical hemostasis, the use of antifibrinolytics, and the restoration of hemodynamics and blood loss contribute to arrest of hemorrhage. Tranexamic acid is listed as an essential drug. This drug has an antifibrinolytic effect, enhances collagen synthesis which helps preserve the fibrin matrix, stabilizes the thrombus, normalizes platelet function and capillary permeability, and prevents the formation of bradykinin, kallikrein, T‑kinin. The experience of using tranexamic acid in injured individuals with signs of massive bleeding, in extensive surgical interventions, in patients with malignant neoplasms and postpartum hemorrhage is highlighted. Clinical studies have shown the efficacy of tranexamic acid in combat injuries, preparing patients for coronary artery bypass grafting, total hip and knee arthroplasty, major surgical operations on the spine, uterine, nasal, gastric and intestinal bleeding, hematuria, bleeding after prostatectomy and tonsillectomy. It has been proven that tranexamic acid reduces the mortality of patients from bleeding during childbirth, in the perioperative period and during injuries, without increasing the risk of thrombotic complications. The approaches are suggested to the use of tranexamic acid for bleeding of various origins according to the British recommendations, the guidelines of the European Association of Anesthetists for the intensive care of massive bleeding, recommendations for tactical medicine of the United States and the American Society of Anesthesiologists. The problem of the effectiveness of the use of this drug is highlighted.
Authors and Affiliations
S. M. Genyk, M. M. Voloshyn, A. V. Simchych
Keywords
Related Articles
- EP ID EP673919
- DOI 10.30978/HV2019-3-81
- Views 109
- Downloads 0
Prognostic significance of soluble ST2 as predictor of late left ventricular remodeling after ST-segment elevation myocardial infarction
The aim — to study the prognostic value of soluble ST2 regarding the development of pathological left ventricular remodeling (LVR) 6 months after acute ST‑ segment elevation myocardial infarction (STEMI) Materials and m...
To the issue of corrosion of occluders from beta-zirconium alloy in experimental study of endovascular devices for the closure of arterial duct
The aim — to evaluate the condition of the surface of intact occluders and its corrosion resistance in the experimental study of devices made of bzirconium alloy after prolonged stay in an animal’s body. Materials and...
Long-term results of treatment of varycose disease by metod of endovasal laser coagulation
The aim — to analyse the post‑operative results of treatment of patients with varicose disease after surgery with the endothermal method. Materials and methods. The research analysis covered 129 patients who underwent...
Endometrioma of the rectus abdominis
Endometriosis is determined if the endometrial tissue is located outside the uterine cavity. Endometrial tissue can be localized in the peritoneum, vagina, scar tissue, cervix, fallopian tubes, rectum, urinary tract, Dou...
Clinical and anamnestic characteristics of patients with acute pulmonary embolism
The aim — to analyze the features of the course and the main factors of development of pulmonary embolism (PE). Materials and methods. During the period from January 1, 2014 until July 1, 2018, 774 patients with acute p...