Vitamin D receptor gene polymorphism in Polish patients with morbid obesity
Journal Title: Postępy Nauk Medycznych - Year 2014, Vol 27, Issue 1
Abstract
Introduction. Obesity has important medical, psychosocial and economic consequences which are greater than those of many other chronic disorders. Active form of vitamin D, 1,25(OH)2D exerts its actions through binding to the vitamin D receptor (VDR). Some data suggest a role of vitamin D and VDR polymorphism in obesity and its metabolic complications.Aim. Our objective was a preliminary evaluation the association of VDR gene FokI and BsmI polymorphism and body mass index (BMI), inflammatory parameters (C-reactive protein – CRP, erythrocyte sedimentation rate – ESR), hypertension, dyslipidemia and hyperglycemia in a morbidly obese Polish patients.Material and methods. The study involved 152 morbidly obese patients (BMI ≥ 40 kg/m2) and 100 healthy controls. DNA was extracted from peripheral blood. Genotyping was performed by real-time PCR using LightSNiP tests with SimpleProbe probes. Melting curve analysis of PCR amplicons enabled identification FokI and BsmI genotypes.Results. There were no significant differences between morbidly obese patients and control subjects in the distribution of FokI and BsmI genotypes or alleles. No association between VDR FokI and BsmI polymorphism was observed with the BMI, CRP, ESR, hypertension, dyslipidemia and hyperglycemia.Conclusions. Based on our results, it can be concluded that FokI and BsmI polymorphism is not associated with the BMI, inflammatory parameters and the frequency of hypertension, dyslipidemia and hyperglycemia in Polish patients with morbid obesity. Our observations should be considered as preliminary. Further studies on larger cohorts of individuals are thus urgently needed to shed more light on the value of assaying the VDR polymorphism in obesity.
Authors and Affiliations
Beata Kaleta, Magdalena Walicka, Ada Sawicka, Małgorzata Wrzosek, Agata Bogołowska-Stieblich, Grażyna Nowicka, Andrzej Górski, Jacek Łukaszkiewicz, Ewa Marcinowska-Suchowierska
Keywords
Related Articles
- EP ID EP54824
- DOI -
- Views 146
- Downloads 0
Assessment of atherosclerotic lesions in coronary arteries using a modified SYNTAX score in patients with diabetes and acute coronary syndrome treated with coronary angioplasty and the prognosis
<b>Introduction and aim.</b> An angiographic score assessing atherosclerotic lesions in coronary arteries, capturing number of lesions, their character, localization, functional influence and...
Genetyka kliniczna raka prostaty
Badania epidemiologiczne ostatniego dwudziestolecia dowodzą, że czynniki genetyczne mają ogromne znaczenie w etiologii raka gruczołu krokowego, jednakże geny związane z dziedziczną predyspozycją do tego nowotworu pozosta...
Genetic test for high risk of breast and ovarian cancers
Mutations in two genes, known as BRCA1 and BRCA2 can be inherited and lead to a markedly increased risk for developing breast cancer and ovarian cancer.In Poland three founder mutations in BRCA1 (5382insC, C61G, 4153delA...
Depression in old age – archetype of affective disorders?
Late-life depressions are heterogenous. The relationship between cardiovascular risk factors and depression is well-known,but during last years is analyzed carefully. There is presumption,that knowledge about pathomechan...
Transarterial chemoembolisation using drug-eluting microspheres (DEM-TACE) in patients suffering liver metastatic disease
<b>Introduction.</b> Liver is one of the major organs suffering from primary and metastatic tumour spread. One of the methods used in nowadays treatment for unresectable metastases in the live...